THE ROLE OF HISTONE DEACETYLASE 6 (HDAC6) IN MUTANT GLYCYL-TRNA SYNTHETASE (GARS) AND MUTANT SMALL HEAT SHOCK PROTEIN B1 (HSPB1)-INDUCED AXONAL CHARCOT-MARIE-TOOTH DISEASE (CMT)

被引:0
|
作者
Benoy, V [1 ,2 ]
Vanden Berghe, P. [3 ]
Bervoets, S. [4 ]
Cader, M. Z. [5 ,6 ]
Talbot, K. [5 ]
Kozikowski, A. [7 ]
Jordanova, A. [4 ]
Van Damme, P. [1 ,2 ,8 ]
Robberecht, W. [1 ,2 ,8 ]
Van den Bosch, L. [1 ,2 ]
机构
[1] Univ Leuven, KU Leuven, Dept Neurosci, Expt Neurol, Leuven, Belgium
[2] VIB, Vesalius Res Ctr, Neurobiol Lab, Leuven, Belgium
[3] Univ Leuven, Translat Res Ctr Gastrointestinal Disorders, Leuven, Belgium
[4] Univ Antwerp, VIB Dept Mol Genet, Mol Neurogen Grp, Antwerp, Belgium
[5] Univ Oxford, John Radcliffe Hosp, Dept Clin Neurosci, Oxford, England
[6] Univ Oxford, John Radcliffe Hosp, Weatherall Inst Mol Med, Oxford, England
[7] Univ Illinois, Drug Discovery Program, Dept Med Chem & Pharmacognosy, Chicago, IL USA
[8] Univ Hosp Leuven, Dept Neurol, Leuven, Belgium
关键词
D O I
暂无
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
引用
收藏
页码:239 / 239
页数:1
相关论文
共 11 条
  • [1] HDAC6 inhibitors reverse axonal loss in a mouse model of mutant HSPB1–induced Charcot-Marie-Tooth disease
    Constantin d'Ydewalle
    Jyothsna Krishnan
    Driss M Chiheb
    Philip Van Damme
    Joy Irobi
    Alan P Kozikowski
    Pieter Vanden Berghe
    Vincent Timmerman
    Wim Robberecht
    Ludo Van Den Bosch
    [J]. Nature Medicine, 2011, 17 : 968 - 974
  • [2] HDAC6 is a therapeutic target in mutant GARS-induced Charcot-Marie-Tooth disease
    Benoy, Veronick
    Van Helleputte, Lawrence
    Prior, Robert
    d'Ydewalle, Constantin
    Haeck, Wanda
    Geens, Natasja
    Scheveneels, Wendy
    Schevenels, Begga
    Cader, M. Zameel
    Talbot, Kevin
    Kozikowski, Alan P.
    Vanden Berghe, Pieter
    Van Damme, Philip
    Robberecht, Wim
    Van Den Bosch, Ludo
    [J]. BRAIN, 2018, 141 : 673 - 687
  • [3] HDAC6 inhibitors reverse axonal loss in a mouse model of mutant HSPB1-induced Charcot-Marie-Tooth disease
    d'Ydewalle, Constantin
    Krishnan, Jyothsna
    Chiheb, Driss M.
    Van Damme, Philip
    Irobi, Joy
    Kozikowski, Alan P.
    Vanden Berghe, Pieter
    Timmerman, Vincent
    Robberecht, Wim
    Van Den Bosch, Ludo
    [J]. NATURE MEDICINE, 2011, 17 (08) : 968 - U86
  • [4] Small Heat-Shock Protein HSPB1 Mutants Stabilize Microtubules in Charcot-Marie-Tooth Neuropathy
    Almeida-Souza, Leonardo
    Asselbergh, Bob
    d'Ydewalle, Constantin
    Moonens, Kristof
    Goethals, Sofie
    de Winter, Vicky
    Azmi, Abdelkrim
    Irobi, Joy
    Timmermans, Jean-Pierre
    Gevaert, Kris
    Remaut, Han
    Van den Bosch, Ludo
    Timmerman, Vincent
    Janssens, Sophie
    [J]. JOURNAL OF NEUROSCIENCE, 2011, 31 (43): : 15320 - 15328
  • [5] Small heat shock protein B3 (HSPB3) mutation in an axonal Charcot-Marie-Tooth disease family
    Nam, Da E.
    Nam, Soo H.
    Lee, Ah J.
    Hong, Young B.
    Choi, Byung-Ok
    Chung, Ki W.
    [J]. JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM, 2018, 23 (01) : 60 - 66
  • [6] CKD-510, A NOVEL NON-HYDROXAMIC ACID HISTONE DEACETYLASE 6 (HDAC6) INHIBITOR FOR CHARCOT-MARIE-TOOTH DISEASE TYPE 1A
    Bae, Daekwon
    Choi, Ji-heon
    Song, Ju Young
    Kim, Mincheol
    Baek, Jiyeon
    Park, Jinsol
    Kwak, Geon
    Kim, Se-mi
    Kim, Heyjin
    Ha, Nina
    [J]. JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM, 2022, 27 : S4 - S4
  • [7] Mutant small heat-shock protein 27 causes axonal Charcot-Marie-Tooth disease and distal hereditary motor neuropathy
    Evgrafov, OV
    Mersiyanova, I
    Irobi, J
    Van Den Bosch, L
    Dierick, I
    Leung, CL
    Schagina, O
    Verpoorten, N
    Van Impe, K
    Fedotov, V
    Dadali, E
    Auer-Grumbach, M
    Windpassinger, C
    Wagner, K
    Mitrovic, Z
    Hilton-Jones, D
    Talbot, K
    Martin, JJ
    Vasserman, N
    Tverskaya, S
    Polyakov, A
    Liem, RKH
    Gettemans, J
    Robberecht, W
    De Jonghe, P
    Timmerman, V
    [J]. NATURE GENETICS, 2004, 36 (06) : 602 - 606
  • [8] Mutant small heat-shock protein 27 causes axonal Charcot-Marie-Tooth disease and distal hereditary motor neuropathy
    Oleg V Evgrafov
    Irena Mersiyanova
    Joy Irobi
    Ludo Van Den Bosch
    Ines Dierick
    Conrad L Leung
    Olga Schagina
    Nathalie Verpoorten
    Katrien Van Impe
    Valeriy Fedotov
    Elena Dadali
    Michaela Auer-Grumbach
    Christian Windpassinger
    Klaus Wagner
    Zoran Mitrovic
    David Hilton-Jones
    Kevin Talbot
    Jean-Jacques Martin
    Natalia Vasserman
    Svetlana Tverskaya
    Alexander Polyakov
    Ronald K H Liem
    Jan Gettemans
    Wim Robberecht
    Peter De Jonghe
    Vincent Timmerman
    [J]. Nature Genetics, 2004, 36 : 602 - 606
  • [9] DISRUPTED AXONAL TRANSPORT IN A MOUSE MODEL OF MUTANT HSPB1-INDUCED CHARCOT-MARIE-TOOTH DISEASE TYPE 2F
    d'Ydewalle, C.
    Krishnan, J.
    Van Damme, P.
    Vanden Berghe, P.
    Timmerman, V
    Robberecht, W.
    Van Den Bosch, L.
    [J]. JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM, 2011, 16 : S32 - S32
  • [10] Small heat-shock protein HSPB8 and HSPB1: Screening in Italian patients with Charcot-Marie-Tooth disease type II and with distal hereditary motor neuropathies
    Varese, A.
    Acquaviva, M.
    Geroldi, M.
    Ciotti, P.
    Schenone, A.
    Doria-Lamba, L.
    Massa, R.
    Mandich, P.
    Bellone, E.
    [J]. JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM, 2006, 11 (02) : 207 - 207