Molecular Epidemiology of Genital Infections in Campania Region: A Retrospective Study

被引:2
|
作者
Scaglione, Elena [1 ,2 ]
Mantova, Giuseppe [1 ]
Caturano, Valeria [1 ]
Fanasca, Luca [1 ]
Carraturo, Francesca [1 ]
Farina, Fabrizio [3 ]
Pagliarulo, Caterina [4 ]
Vitiello, Mariateresa [1 ]
Pagliuca, Chiara [1 ]
Salvatore, Paola [1 ,5 ]
Colicchio, Roberta [1 ]
机构
[1] Univ Napoli Federico II, Dept Mol Med & Med Biotechnol, Via S Pansini 5, I-80131 Naples, Italy
[2] Univ Napoli Federico II, Dept Chem Mat & Prod Engn, Piazzale V Tecchio 80, I-80125 Naples, Italy
[3] Univ Sannio, Dept Law Econ Management & Quantitat Methods, Piazza Arechi II, I-82100 Benevento, Italy
[4] Univ Sannio, Dept Sci & Technol, Via De Sanctis, I-82100 Benevento, Italy
[5] CEINGE Biotecnol Avanzate Scarl, Via Gaetano Salvatore 486, I-80145 Naples, Italy
关键词
genital infections; multiplex real-time PCR; epidemiology; UREAPLASMA-UREALYTICUM; MYCOPLASMA-HOMINIS; TRICHOMONAS-VAGINALIS; NEISSERIA-GONORRHOEAE; CHLAMYDIA-TRACHOMATIS; PREVALENCE; WOMEN; PARVUM; PCR; DISEASE;
D O I
10.3390/diagnostics12081798
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
This study provides updated information on the prevalence and co-infections caused by genital microorganisms and pathogens: Mycoplasma genitalium, Mycoplasma hominis, Ureaplasma parvum, Ureaplasma urealyticum, Trichomonas vaginalis, and Gardnerella vaginalis, by retrospectively analyzing a cohort of patients living in the Naples metropolitan area, Campania region, Southern Italy. To investigate the genital infections prevalence in clinical specimens (vaginal/endocervical swabs and urines) collected from infertile asymptomatic women and men from November 2018 to December 2020, we used a multiplex real-time PCR assay. Of the 717 specimens collected, 302 (42.1%) resulted positive for at least one of the targets named above. Statistically significant differences in genital prevalence of selected microorganisms were detected in both women (62.91%) and men (37.08%). G. vaginalis and U. parvum represented the most common findings with an 80.2% and 16.9% prevalence in vaginal/endocervical swabs and first-voided urines, respectively. Prevalence of multiple infections was 18.18% and 8.19% in women and men, respectively. The most frequent association detected was the co-infection of G. vaginalis and U. parvum with 60% prevalence. Our epidemiological analysis suggests different infection patterns between genders, highlighting the need to implement a preventative screening strategy of genital infections to reduce the complications on reproductive organs.
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页数:11
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