Silyl group deprotection by Pd/C/H2.: A facile and selective method

被引：18
|
作者：
Kim, S
Jacobo, SM
Chang, CT
Bellone, S
Powell, WS
Rokach, J
机构：
[1] Florida Inst Technol, Claude Pepper Inst, Melbourne, FL 32901 USA
[2] Florida Inst Technol, Dept Chem, Melbourne, FL 32901 USA
[3] McGill Univ, Meakins Christie Labs, Dept Med, Montreal, PQ H2X 2P2, Canada
来源：
TETRAHEDRON LETTERS | 2004年 / 45卷 / 09期
基金：
美国国家卫生研究院; 加拿大健康研究院; 美国国家科学基金会;
关键词：
hydrogenolysis; TES; TPS; TBS; TBDMS; TIPS; TBDPS;
D O I：
10.1016/j.tetlet.2003.12.145
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An easy, high yield, RT, short-reaction-time Pd/C hydrogenation of silyl groups is described. This includes TES, TPS, TBS, TBDMS, TIPS, and TBDPS. The relative selectivity of the process has been investigated and we can show, for example, that TES, TPS, TBS, and TBDMS removal can be performed in the presence of TIPS and TBDPS. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1973 / 1976
页数：4
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