Drug discovery in the next decade: innovation needed ASAP

被引：10

作者：

Bennani, Youssef L. ^{[1
]}

机构：

[1] Vertex Pharmaceut, Cambridge, MA 02139 USA

来源：

DRUG DISCOVERY TODAY | 2012年 / 17卷

关键词：

PROTEIN-COUPLED RECEPTORS; RESEARCH-AND-DEVELOPMENT; NATURAL-PRODUCTS; MOUSE MODELS; BINDING; DESIGN; METABOLISM; MODULATORS; INHIBITOR; EZETIMIBE;

D O I：

10.1016/j.drudis.2011.12.007

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Pharmaceutical companies must find a better way to increase their output of truly new drugs for the benefit of patients and for their business survival. Here, I highlight a general perspective from within pharmaceutical research as it pertains to research advances in chemistry, biology, pharmacology, pharmacokinetics and toxicology that, if well integrated, stands to put the industry on a productive path. In addition, I provide a complementary perspective on the corporate culture aspect of innovation. I also introduce a new concept, termed 'innovation ASAP' (iASAP; asking powerful questions, seeking the outliers, accepting defeat and populating astutely) and provide support for it using examples of several successful drugs.

引用

页码：S31 / S44

页数：14

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