Hepatocellular carcinoma with progenitor cell features distinguishable by the hepatic stem/progenitor cell marker NCAM

被引：27

作者：

Tsuchiya, Atsunori ^{[1
]}

Kamimura, Hiroteru ^{[1
]}

Tamura, Yasushi ^{[1
]}

Takamura, Masaaki ^{[1
]}

Yamagiwa, Satoshi ^{[1
]}

Suda, Takeshi ^{[1
]}

Nomoto, Minoru ^{[1
]}

Aoyagi, Yutaka ^{[1
]}

机构：

[1] Niigata Univ, Div Gastroenterol & Hepatol, Grad Sch Med & Dent Sci, Chuo Ku, Niigata 9518510, Japan

来源：

CANCER LETTERS | 2011年 / 309卷 / 01期

关键词：

NCAM; HCC with progenitor features; Soluble NCAM; FGFR; Intrahepatic metastasis; ADHESION MOLECULE; LUNG-CANCER; STEM-CELLS; E-CADHERIN; EXPRESSION; TUMORS; LIVER; METASTASIS;

D O I：

10.1016/j.canlet.2011.05.021

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We analyzed hepatocellular carcinoma (HCC) with progenitor cell features using hepatic stem/progenitor cell marker neural cell adhesion molecule (NCAM). Approximately 8.3% of the operated HCC cases expressed NCAM, and 22.3% of the HCC patients had soluble NCAM levels >1000 ng/ml (the "highly soluble" NCAM group). Soluble NCAM status was a significant independent factor predictive of long-term survival in patients with HCC, and high levels of soluble NCAM were significantly related to intrahepatic metastasis. The 140-kDa NCAM isoform was specifically detected in the "highly soluble" NCAM group of HCC patients and its related signals are potential drug targets for NCAM+ HCC. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

引用

页码：95 / 103

页数：9

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