Vacancy-enhanced generation of singlet oxygen for photodynamic therapy

被引:53
|
作者
Guan, Shanyue [1 ]
Wang, Li [1 ,2 ]
Xu, Si-Min [3 ]
Yang, Di [2 ]
Waterhouse, Geoffrey I. N. [4 ]
Qu, Xiaozhong [2 ]
Zhou, Shuyun [1 ]
机构
[1] Chinese Acad Sci, Key Lab Photochem Convers & Optoelect Mat, Tech Inst Phys & Chem, Beijing 100190, Peoples R China
[2] Univ Chinese Acad Sci, Coll Mat Sci & Optoelect Technol, Beijing 100049, Peoples R China
[3] Beijing Univ Chem Technol, State Key Lab Chem Resource Engn, Beijing 100029, Peoples R China
[4] Univ Auckland, Sch Chem Sci, Auckland 1142, New Zealand
基金
中国国家自然科学基金; 以色列科学基金会;
关键词
POLYPYRIDYL COMPLEXES; NANOPARTICLES; BIOBR; PHOTOSENSITIZERS; NANOSHEETS; MECHANISM; OXIDATION; HYPOXIA;
D O I
10.1039/c8sc05275a
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Oxygen vacancy (OV) engineering in semiconductors can greatly enhance the separation of photo-induced electron-hole pairs, thereby enhancing the photocatalytic activity. Taking inspiration from this, we prepared a novel BiOBr-H/Rub(2)d composite by functionalizing OV-rich BiOBr (named BiOBr-H) with a carboxyl functionalized ruthenium photosensitizer (Ru(bpy)(2)C-pyCl(2), abbreviated as Rub(2)d), which was then successfully applied for photodynamic therapy (PDT). Density functional theory (DFT) calculations confirmed efficient electron transfer from the Rub(2)d complex to the intermediate energy level of BiOBr-H under visible light irradiation. In vitro and in vivo studies demonstrated that BiOBr-H/Rub(2)d was a superior agent for photodynamic therapy compared with the free ruthenium complex. The theoretical and experimental data presented thus reveal for the first time that abundant OVs in BiOBr-H can significantly improve the photocatalytic activity of a photosensitizer, resulting in the generation of more reactive oxygen species to enhance PDT. The findings of this study thus offer a new strategy for the development of highly efficient cancer therapies.
引用
收藏
页码:2336 / 2341
页数:6
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