Gold decorated NaYF4:Yb,Er/NaYF4/silica (core/shell/shell) upconversion nanoparticles for photothermal destruction of BE(2)-C neuroblastoma cells

被引：59
|
作者：
Qian, Li Peng [1 ]
Zhou, Li Han [2 ,3 ]
Too, Heng-Phon [2 ,3 ]
Chow, Gan-Moog [1 ]
机构：
[1] Natl Univ Singapore, Dept Mat Sci & Engn, Singapore 117540, Singapore
[2] Natl Univ Singapore, Dept Biochem, Singapore 119260, Singapore
[3] Singapore Massachusetts Inst Technol Alliance, Singapore 117576, Singapore
来源：
JOURNAL OF NANOPARTICLE RESEARCH | 2011年 / 13卷 / 02期
关键词：
Upconversion; Gold; Photothermal therapy; Nanocomposites; Nanomedicine; SILICA SPHERES; THERAPY; FLUORESCENCE; NANOSHELLS; NANOCRYSTALS; LUMINESCENCE; ENHANCEMENT; EXCITATION; ABLATION; TUMORS;
D O I：
10.1007/s11051-010-0080-6
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Gold decorated NaYF4:Yb,Er/NaYF4/silica (core/shell/shell) upconversion (UC) nanoparticles (similar to 70-80 nm) were synthesized using tetraethyl orthosilicate and chloroauric acid in a one-step reverse microemulsion method. Gold nanoparticles (similar to 6 nm) were deposited on the surface of silica shell of these core/shell/shell nanoparticles. The total upconversion emission intensity (green, red, and blue) of the core/shell/shell nanoparticles decreased by similar to 31% after Au was deposited on the surface of silica shell. The upconverted green light was coupled with the surface plasmon of Au leading to rapid heat conversion. These UC/silica/Au nanoparticles were very efficient to destroy BE(2)-C cancer cells and showed strong potential in photothermal therapy.
引用
收藏
页码：499 / 510
页数：12
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