Eculizumab as a promising treatment in thymoma-associated myasthenia gravis

被引：9

作者：

Velez-Santamaria, Valentina ^{[2
,3
]}

Nedkova, Velina ^{[3
]}

Diez, Laura ^{[3
]}

Homedes, Christian ^{[3
]}

Alberti, M. Antonia ^{[3
]}

Casasnovas, Carlos ^{[1
]}

机构：

[1] Bellvitge Univ Hosp, Neuromuscular Unit, Neurol Dept, N-N Feixa Llarga St, Barcelona 08906, Spain

[2] Bellvitge Biomed Res Inst IDIBELL, Neurometab Dis Grp, Barcelona, Spain

[3] Bellvitge Univ Hosp, Neurol Dept, Barcelona, Spain

来源：

THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS | 2020年 / 13卷

关键词：

case report; complement inhibitor; eculizumab; myasthenia gravis; refractory; thymoma;

D O I：

10.1177/1756286420932035

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Myasthenia gravis is a chronic autoimmune disorder caused by antibodies directed against the neuromuscular junction. Some patients may have an associated thymoma, which confers a worse prognosis. Eculizumab, a monoclonal antibody that inhibits the activation of terminal complement, has recently been approved for the treatment of refractory generalized myasthenia gravis. This is an early case report of thymoma-associated refractory myasthenia gravis successfully treated with eculizumab in a real-world setting.

引用

页数：4

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