Management of a Prostate Cancer Patient With Inherited Germline BRCA1 and BRCA2 Mutations: A Case Report

被引：1
|
作者：
Hemal, Sij [1 ]
DeWitt-Foy, Molly [1 ]
Klein, Eric A. [1 ]
机构：
[1] Cleveland Clin Fdn, Dept Urol, Glickman Urol & Kidney Inst, Cleveland, OH 44195 USA
来源：
UROLOGY | 2021年 / 153卷
关键词：
D O I：
10.1016/j.urology.2020.11.076
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
The Breast Cancer Gene (BRCA) confers an 8.6-fold higher risk of developing prostate cancer in men < 65 years of age and portends a worse prognosis as compared to noncarriers even in patients with low volume, localized disease. The BRCA2 gene, in particular, imparts a more biologically aggressive form of prostate cancer and a higher prostate cancer specific mortality. From a treatment standpoint, this translates to worse overall clinical outcomes for such patients. The most appropriate screening and management strategy for germline BRCA mutation carriers with prostate cancer is not known. Herein, we present an incidentally discovered prostate cancer in a 61-year-old BRCA1 and BRCA2 germline mutation carrier who was screened and managed using an individualized treatment approach. (C) 2021 Elsevier Inc.
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收藏
页码：129 / 131
页数：3
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