Hydropyrolysis of steroids: a preparative step for compound-specific carbon isotope ratio analysis

被引：7
|
作者：
Sephton, MA
Meredith, W
Sun, CG
Snape, CE
机构：
[1] Univ London Imperial Coll Sci & Technol, Dept Earth Sci & Engn, London SW7 2AZ, England
[2] Univ Nottingham, Sch Chem Environm & Min Engn, Nottingham NG7 2RD, England
来源：
RAPID COMMUNICATIONS IN MASS SPECTROMETRY | 2005年 / 19卷 / 22期
基金：
英国自然环境研究理事会;
关键词：
D O I：
10.1002/rcm.2201
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Compound-specific stable carbon isotope analysis by gas chromatography/combustion/isotope ratio mass spectrometry is an important method for the detection of steroid abuse in athletes. However, steroids in their natural form exhibit poor chromatographic resolution, while derivatization adds carbon thereby corrupting the starting stable isotopic composition. Hydropyrolysis is a new approach, which defunctionalizes steroids but leaves their carbon skeleton intact. The process improves chromatography, allowing the faithful measurement of carbon isotope ratios and enabling a more effective apportionment for the source of steroids and their metabolites. Copyright (c) 2005 John Wiley & Sons, Ltd.
引用
收藏
页码：3339 / 3342
页数：4
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