Peptide and peptidomimetic ligands for CXC chemokine receptor 4 (CXCR4)

被引：25
|
作者：
Oishi, Shinya [1 ]
Fujii, Nobutaka [1 ]
机构：
[1] Kyoto Univ, Grad Sch Pharmaceut Sci, Sakyo Ku, Kyoto 6068501, Japan
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2012年 / 10卷 / 30期
关键词：
ANTI-HIV PEPTIDE; IMMUNODEFICIENCY-VIRUS ACTIVITY; CELL FUSION INHIBITOR; N-TERMINAL PEPTIDES; SMALL-MOLECULE; SYNTHETIC PEPTIDE; BONE-MARROW; FACTOR-I; THERAPEUTIC TARGET; PHARMACOPHORE IDENTIFICATION;
D O I：
10.1039/c2ob25107h
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The development of novel peptide and peptidomimetic ligands for the CXC chemokine receptor 4 (CXCR4) as therapeutic agents for HIV-1 infection, cancer, and immune system diseases has grown over the last decade. In this perspective article, the design of CXCR4 agonists and antagonists from endogenous stromal cell-derived factor-1 (SDF-1)/CXCL12 and horseshoe crab-derived antimicrobial peptides and their therapeutic and diagnostic applications are described.
引用
收藏
页码：5720 / 5731
页数：12
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