Phytoestrogens oestrogen synthesis and breast cancer

被引：36
|
作者：
Rice, Suman [1 ]
Whitehead, Saffron A. [1 ]
机构：
[1] St Georges Univ London, Div Basic Med Sci, London SW17 0RE, England
来源：
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY | 2008年 / 108卷 / 3-5期
关键词：
phytoestrogens; oestrogen receptors; aromatase; 17; beta-HSD; sulphatase; breast cancer;
D O I：
10.1016/j.jsbmb.2007.09.003
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Phytoestrogens are used as 'natural' alternatives to HRT and, although epidemiological evidence implies that diets rich in phytoestrogens reduce the incidence of breast cancer, their weak oestrogenicity is also known to stimulate growth in experimental models of breast cancer. This review addresses the question as to how phytoestrogens may protect against breast cancer through their ability to bind preferentially to oestrogen receptor P, inhibit enzymes that convert circulating steroid precursors into oestradiol and inhibit cell signalling pathways of growth factors. (c) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：186 / 195
页数：10
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