Dibenzocyclooctane lignans from the stems of Schisandra bicolor

A new dibenzocyclooctane lignan, schisanbicolorin A, together with fifteen known lignans, were isolated from the stems of Schisandra bicolor Cheng. Their structures were identified as (aS,6R,75)-5,6,7,8-tetrahydro-2,3,13-trimethoxy-6,7-dimethyldibenzo[3,4]cycloocta [1,2-f][1,3]benzodioxol-1-ol (1), neglschisandrin C (2), angeloylgomisin R (3), schisantherin D (4), gomisin F (5), schisantherin B (6), tigloylgomisin Q (7), gomisin G (8), interiotherin B (9), schisandrin (10), angeloylgomisin H (11), benzoylgomisin H (12), gomisin H (13), angeloyl-(+)-gomisin K-3 (14), deoxyschizandrin (15), and (+)-gomisin K-3 (16), respectively, based on spectroscopic analysis and by comparison of their spectral data with those reported previously in the literature. Crown Copyright (C) 2010 Published by Elsevier Ltd. All rights reserved.