Role of EphA4 in Mediating Motor Neuron Death in MND

被引：7

作者：

Zhao, Jing ^{[1
]}

Stevens, Claire H. ^{[2
,3
]}

Boyd, Andrew W. ^{[4
]}

Ooi, Lezanne ^{[2
,3
]}

Bartlett, Perry F. ^{[1
]}

机构：

[1] Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia

[2] Illawarra Hlth & Med Res Inst, Wollongong, NSW 2522, Australia

[3] Univ Wollongong, Sch Chem & Mol Biosci & Mol Horizons, Wollongong, NSW 2522, Australia

[4] Univ Queensland, Sch Med, Brisbane, Qld 4072, Australia

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 17期

关键词：

receptors; Eph; EphA4; motor neurons; motor neuron death; neurodegenerative disease; motor neuron disease; pathogenesis; AMYOTROPHIC-LATERAL-SCLEROSIS; IMPROVES FUNCTIONAL RECOVERY; D-ASPARTATE RECEPTORS; RHO-KINASE; D-SERINE; DISEASE; ACTIVATION; INHIBITION; GLUTAMATE; RILUZOLE;

D O I：

10.3390/ijms22179430

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Motor neuron disease (MND) comprises a group of fatal neurodegenerative diseases with no effective cure. As progressive motor neuron cell death is one of pathological characteristics of MND, molecules which protect these cells are attractive therapeutic targets. Accumulating evidence indicates that EphA4 activation is involved in MND pathogenesis, and inhibition of EphA4 improves functional outcomes. However, the underlying mechanism of EphA4's function in MND is unclear. In this review, we first present results to demonstrate that EphA4 signalling acts directly on motor neurons to cause cell death. We then review the three most likely mechanisms underlying this effect.

引用

页数：13

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