Plumieride exerts anxiolytic-like effect mediated by GABAergic and monoaminergic systems

被引：5
|
作者：
Dalmagro, Ana Paula [1 ]
Camargo, Anderson [3 ]
Zimath, Priscila Laiz [1 ]
Bonomini, Tiago Jose [1 ]
Zeni, Ana Lucia Bertarello [2 ]
Malheiros, Angela [1 ]
de Souza, Marcia Maria [1 ]
机构：
[1] Univ Vale Itajai Univ, Programa Posgrad Ciencias Farmaceut, Nucleo Invest Quim Farmaceut NIQFAR, Itajai, SC, Brazil
[2] Univ Reg Blumenau FURB, Lab Avaliacao Subst Bioat, Dept Ciencias Nat, Blumenau, SC, Brazil
[3] Univ Fed Santa Catarina, Programa Posgrad Neurociencias, Ctr Ciencias Biol, Florianopolis, SC, Brazil
来源：
NATURAL PRODUCT RESEARCH | 2021年 / 35卷 / 22期
关键词：
Plumieride; iridoid; anxiolytic; monoaminergic; GABAergic;
D O I：
10.1080/14786419.2020.1737052
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Plumieride (PLU), an iridoid isolated from Allamanda cathartica flowers, has been studied by our research group due to its anti-inflammatory potential, antidepressant-like and anxiolytic-like effects. This research investigated the involvement of GABAergic and monoaminergic systems in the anxiolytic-like effect elicited by PLU. Therefore, mice were pre-treated with GABAergic, serotonergic, adrenergic or dopaminergic receptor antagonists (i.p.), and exposed to Elevated Plus-Maze (EPM) and Open-Field Test (OFT). The preliminary results revealed that PLU (p.o.) possibly interacts with the mentioned systems through the GABA(A), GABA(B), 5-HT1A, 5-HT3, alpha(1), alpha(2), and D-2 receptors.
引用
收藏
页码：4849 / 4852
页数：4
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