Immunotherapy of Brain Cancers: The Past, the Present, and Future Directions

被引：7

作者：

Ge, Lisheng ^{[1
,2
]}

Hoa, Neil ^{[1
,2
]}

Bota, Daniela A. ^{[3
,4
]}

Natividad, Josephine ^{[1
,2
]}

Howat, Andrew ^{[1
,2
]}

Jadus, Martin R. ^{[1
,2
,5
,6
]}

机构：

[1] VA Long Beach Healthcare Syst, Dept Diagnost, Pathol & Lab Med Serv, Long Beach, CA 90822 USA

[2] VA Long Beach Healthcare Syst, Mol Med Hlth Care Grp, Long Beach, CA 90822 USA

[3] Univ Calif Irvine, UC Irvine Sch Med, Chao Family Comprehens Canc Ctr, Dept Neurol, Irvine, CA 92697 USA

[4] Univ Calif Irvine, UC Irvine Sch Med, Chao Family Comprehens Canc Ctr, Dept Neurol Surg, Irvine, CA 92697 USA

[5] Univ Calif Irvine, Irvine Sch Med, UC, Chao Family Comprehens Canc Ctr, Irvine, CA 92697 USA

[6] Univ Calif Irvine, Pathol & Lab Med, Irvine, CA 92697 USA

来源：

CLINICAL & DEVELOPMENTAL IMMUNOLOGY | 2010年

关键词：

COLONY-STIMULATING FACTOR; ACTIVATED KILLER-CELLS; HEAT-SHOCK PROTEINS; TUMOR-INFILTRATING LYMPHOCYTES; PRIMARY INTRACRANIAL TUMORS; CYTOTOXIC T-LYMPHOCYTES; CYTOKINE GENE-THERAPY; HIGH-GRADE GLIOMAS; STEM-LIKE CELLS; FACTOR MM-CSF;

D O I：

10.1155/2010/296453

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Treatment of brain cancers, especially high grade gliomas (WHO stage III and IV) is slowly making progress, but not as fast as medical researchers and the patients would like. Immunotherapy offers the opportunity to allow the patient's own immune system a chance to help eliminate the cancer. Immunotherapy's strength is that it efficiently treats relatively small tumors in experimental animal models. For some patients, immunotherapy has worked for them while not showing long-term toxicity. In this paper, we will trace the history of immunotherapy for brain cancers. We will also highlight some of the possible directions that this field may be taking in the immediate future for improving this therapeutic option.

引用

页数：19

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