Working memory capacity predicts dopamine synthesis capacity in the human striatum

被引:213
|
作者
Cools, Roshan [1 ,2 ]
Gibbs, Sasha E. [1 ]
Miyakawa, Asako [1 ]
Jagust, William [1 ,3 ]
D'Esposito, Mark [1 ]
机构
[1] Univ Calif Berkeley, Helen Wills Neurosci Inst, Berkeley, CA 94720 USA
[2] Radboud Univ Nijmegen, FC Donders Ctr Cognit Neuroimaging, NL-6500 HB Nijmegen, Netherlands
[3] Univ Calif Berkeley, Lawrence Berkeley Lab, Berkeley, CA 94720 USA
来源
JOURNAL OF NEUROSCIENCE | 2008年 / 28卷 / 05期
关键词
dopamine; working memory; striatum; listening span; PET; cognition; prefrontal cortex;
D O I
10.1523/JNEUROSCI.4475-07.2008
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Evidence from psychopharmacological research has revealed that dopamine receptor agents have opposite effects on cognitive function depending on baseline levels of working memory capacity. These contrasting effects have been interpreted to reflect differential baseline levels of dopamine. Here we demonstrate for the first time that working memory capacity as measured by listening span predicts dopamine synthesis capacity in the striatum, indicating that subjects with low working memory capacity have low DA synthesis capacity in the striatum, whereas subjects with high working memory capacity have high DA synthesis capacity in the striatum.
引用
收藏
页码:1208 / 1212
页数:5
相关论文
共 50 条
  • [1] Working memory capacity predicts workload capacity
    Yu, Ju-Chi
    Chang, Ting-Yun
    Yang, Cheng-Ta
    [J]. VISUAL COGNITION, 2014, 22 (08) : 1046 - 1049
  • [2] Working memory capacity predicts effective multitasking
    Pollard, Megan A.
    Courage, Mary L.
    [J]. COMPUTERS IN HUMAN BEHAVIOR, 2017, 76 : 450 - 462
  • [3] Working memory capacity predicts the beneficial effect of selective memory retrieval
    Schlichting, Andreas
    Aslan, Alp
    Holterman, Christoph
    Baeuml, Karl-Heinz T.
    [J]. MEMORY, 2015, 23 (05) : 786 - 794
  • [4] Working memory capacity predicts language comprehension in schizophrenic patients
    Condray, R
    Steinhauer, SR
    vanKammen, DP
    Kasparek, A
    [J]. SCHIZOPHRENIA RESEARCH, 1996, 20 (1-2) : 1 - 13
  • [5] Contributions to working memory capacity: Dopamine, genetics and distractor resistance
    McNab, Fiona
    Klingberg, Torkel
    Soderqvist, Stina
    [J]. NEUROSCIENCE RESEARCH, 2010, 68 : E42 - E42
  • [6] Working memory capacity of biological movements predicts empathy traits
    Gao, Zaifeng
    Ye, Tian
    Shen, Mowei
    Perry, Anat
    [J]. PSYCHONOMIC BULLETIN & REVIEW, 2016, 23 (02) : 468 - 475
  • [7] Spatial Working Memory Capacity Predicts Bias in Estimates of Location
    Crawford, L. Elizabeth
    Landy, David
    Salthouse, Timothy A.
    [J]. JOURNAL OF EXPERIMENTAL PSYCHOLOGY-LEARNING MEMORY AND COGNITION, 2016, 42 (09) : 1434 - 1447
  • [8] Working memory capacity predicts conflict-task performance
    Gulbinaite, Rasa
    Johnson, Addie
    [J]. QUARTERLY JOURNAL OF EXPERIMENTAL PSYCHOLOGY, 2014, 67 (07): : 1383 - 1400
  • [9] Working memory capacity of biological movements predicts empathy traits
    Zaifeng Gao
    Tian Ye
    Mowei Shen
    Anat Perry
    [J]. Psychonomic Bulletin & Review, 2016, 23 : 468 - 475
  • [10] Working Memory Capacity Predicts Effects of Methylphenidate on Reversal Learning
    van der Schaaf, Marieke E.
    Fallon, Sean J.
    ter Huurne, Niels
    Buitelaar, Jan
    Cools, Roshan
    [J]. NEUROPSYCHOPHARMACOLOGY, 2013, 38 (10) : 2011 - 2018