Effects of Statin Treatment on Cardiac Function in Patients With Chronic Heart Failure: A Meta-Analysis of Randomized Controlled Trials

被引:28
|
作者
Zhang, Lei [1 ]
Zhang, Shuning [1 ]
Jiang, Hong [1 ]
Sun, Aijun [1 ]
Zou, Yunzeng [1 ,2 ]
Ge, Junbo [1 ,2 ]
机构
[1] Fudan Univ, Shanghai Med Coll, Zhongshan Hosp, Shanghai Inst Cardiovasc Dis, Shanghai 200032, Peoples R China
[2] Fudan Univ, Shanghai Med Coll, Inst Biomed Sci, Shanghai 200032, Peoples R China
基金
中国国家自然科学基金;
关键词
EXPERIMENTAL MYOCARDIAL-INFARCTION; SCANDINAVIAN SIMVASTATIN SURVIVAL; BRAIN NATRIURETIC PEPTIDE; COA REDUCTASE INHIBITOR; TUMOR-NECROSIS-FACTOR; DILATED CARDIOMYOPATHY; INFLAMMATORY MARKERS; ENDOTHELIAL FUNCTION; DOUBLE-BLIND; IN-VITRO;
D O I
10.1002/clc.20821
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Whether additional benefit can be achieved with the use of statin treatment in patients with chronic heart failure (CHF) remains undetermined. Hypothesis: Statin treatment may be effective in improving cardiac function and ameliorating ventricular remodeling in CHF patients. Methods: The PubMed, MEDLINE, EMBASE, and EBM Reviews databases were searched for randomized controlled trials comparing statin treatment with nonstatin treatment in patients with CHF. Two reviews independently assessed studies and extracted data. Weighted mean differences (WMD) with 95% confidence intervals (CI) were calculated using random effects models. Results: Eleven trials with 590 patients were included. Pooled analysis showed that statin treatment was associated with a significant increase in left ventricular ejection fraction (WMD: 3.35%, 95% CI: 0.80 to 5.91%, P = 0.01). The beneficial effects of statin treatment were also demonstrated by the reduction of left ventricular end-diastolic diameter (WMD: -3.77 mm, 95% CI: -6.24 to -1.31 mm, P = 0.003), left ventricular end-systolic diameter (WMD: -3.57 mm, 95% CI: -6.37 to -0.76 mm, P = 0.01), B-type natriuretic peptide (WMD: -83.17 pg/mL, 95% CI: -121.29 to -45.05 pg/mL, P < 0.0001), and New York Heart Association functional class (WMD: -0.30, 95% CI: -0.37 to -0.23, P < 0.00001). Meta-regression showed a statistically significant association between left ventricular ejection fraction improvement and follow-up duration (P = 0.03). Conclusions: The current cumulative evidence suggests that use of statin treatment in CHF patients may result in the improvement of cardiac function and clinical symptoms, as well as the amelioration of left ventricular remodeling.
引用
收藏
页码:117 / 123
页数:7
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