Physicochemical characterization of zofenopril inclusion complex with 2-hydroxypropyl-β-cyclodextrin

被引:8
|
作者
Udrescu, Lucretia [1 ,2 ]
Sbarcea, Laura [1 ]
Fulias, Adriana [1 ]
Ledeti, Ionut [1 ]
Vlase, Titus [3 ]
Barvinschi, Paul [4 ]
Kurunczi, Ludovic [1 ,2 ]
机构
[1] Univ Med & Pharm, Fac Pharm, Timisoara 300041, Romania
[2] Romanian Acad, Inst Chem Timisoara, Timisoara 300223, Romania
[3] West Univ Timisoara, Res Ctr Thermal Anal Environm Problems, Timisoara 300115, Romania
[4] West Univ Timisoara, Fac Phys, Timisoara 300223, Romania
关键词
Job's plot; ATR-FTIR; PXRD; thermal analysis; solubility; HYDROXYPROPYL-BETA-CYCLODEXTRIN; CONVERTING ENZYME-INHIBITOR; CARDIOPROTECTIVE PROPERTIES; CLASSIFICATION-SYSTEM; SOLUBILITY; DISSOLUTION; FOSINOPRIL; STABILITY; CALCIUM;
D O I
10.2298/JSC140828118U
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Zofenopril calcium (ZOF) is one of the newest angiotensin-converting enzyme (ACE) inhibitors, highly lipophilic and with low water solubility. This research investigates the interaction between ZOF and a chemically modified derivative of beta-cyclodextrin, 2-hydroxypropyl-beta-cyclodextrin (HPBCD), in order to prove the formation of an inclusion complex with an enhanced water solubility profile of ZOF. In this research, for the first time, the physicochemical characterization and the solubility profile of an inclusion complex between ZOF and HPBCD are reported. Different spectroscopic techniques (UV absorption spectrometry, powder X-ray diffraction, attenuated total reflectance Fourier transform IR spectroscopy) were applied in order to prove the formation of the ZOF/HPBCD inclusion complex, both in water and in the solid state, backed by thermal analysis (TGA/DTG/HF). The obtained results confirmed that the physicochemical properties of the ZOF/HPBCD binary system, prepared using the kneading method, are different in comparison to both with the parent substances and the corresponding physical mixture, thus suggesting that an inclusion complex was formed. After the formation of the inclusion complex with HPBCD, the solubility test indicated that the water solubility of ZOF was increased 5-fold.
引用
收藏
页码:485 / 497
页数:13
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