Silver-Catalyzed Decarboxylative Radical Addition/Cyclization of α,α-Difluoroarylacetic Acids with Acrylamides To Synthesize Difluorinated Oxindoles

被引：20
|
作者：
Li, Yin-Long [1 ,2 ]
Wang, Ji-Bo [2 ]
Wang, Xue-Lin [2 ]
Cao, Yang [2 ]
Deng, Jun [1 ,2 ]
机构：
[1] Chongqing Univ, Sch Pharmaceut Sci, Chongqing Key Lab Nat Prod Synth & Drug Res, Chongqing 401331, Peoples R China
[2] Tianjin Univ, Sch Pharmaceut Sci & Technol, Tianjin 300072, Peoples R China
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2017年 / 2017卷 / 40期
基金：
中国国家自然科学基金;
关键词：
Fluorinated compounds; Silver; Radical reactions; Cyclization; Nitrogen heterocycles; ALIPHATIC CARBOXYLIC-ACIDS; ARYL BORONIC ACIDS; AQUEOUS-SOLUTION; DIFLUOROALKYLATED ARENES; PHOTOREDOX CATALYSIS; BOND FORMATION; NICKEL; ALKYNYLATION; FLUORINATION; TRIFLUORIDE;
D O I：
10.1002/ejoc.201701248
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A facile silver-catalyzed decarboxylative radical addition/cyclization reaction of alpha,alpha-difluoroarylacetic acids and acrylamides has been disclosed. The method provides a highly attractive approach to synthesize a series of difluorinated oxindoles that contain various functional groups in moderate to good yields under mild conditions. Moreover, experimental studies reveal that the CF2 group of the ,-difluoroarylacetic acids plays a vital role in the transformation.
引用
收藏
页码：6052 / 6059
页数：8
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