Nrf2, a Potential Therapeutic Target against Oxidative Stress in Corneal Diseases

被引：20

作者：

Liu, Xiu-Fen ^{[1
]}

Zhou, Dan-Dan ^{[2
]}

Xie, Tian ^{[3
]}

Malik, Tayyab Hamid ^{[4
]}

Lu, Cheng-Bo ^{[5
]}

Li, Hai-Jun ^{[6
]}

Wang, Fan ^{[1
]}

Shu, Chang ^{[7
]}

Liu, Cong ^{[1
]}

Lu, Cheng-Wei ^{[1
]}

Hao, Ji-Long ^{[1
]}

机构：

[1] Jilin Univ, Dept Ophthalmol, Hosp 1, Changchun, Jilin, Peoples R China

[2] Jilin Univ, Dept Radiol, Hosp 1, Changchun, Jilin, Peoples R China

[3] Peoples Hosp Jilin Prov, Dept Neurosurg, Changchun, Jilin, Peoples R China

[4] Jilin Univ, Hosp 1, Dept Gastroenterol, Changchun, Jilin, Peoples R China

[5] Jiamusi Univ, Hosp 1, Dept Cardiol, Jiamusi, Heilongjiang, Peoples R China

[6] Jilin Univ, Hosp 1, Translat Med Res Inst, Changchun, Jilin, Peoples R China

[7] Jilin Univ, Hosp 1, Dept Obstet & Gynecol, Changchun, Jilin, Peoples R China

来源：

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY | 2017年 / 2017卷

关键词：

NRF2-REGULATED ANTIOXIDANT DEFENSE; ENGINEERED CELL SHEETS; INDUCED APOPTOSIS; EPITHELIAL-CELLS; SLC4A11; DJ-1; DYSTROPHY; MUTATIONS; PROTEIN; MYOFIBROBLASTS;

D O I：

10.1155/2017/2326178

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Corneal diseases are one of the major causes of blindness worldwide. Conservative medical agents, which may prevent sight-threatening corneal disease progression, are urgently desired. Numerous evidences have revealed the involvement of oxidative stress in various corneal diseases, such as corneal wound healing and Fuchs endothelial corneal dystrophy (FECD). Nuclear factor (erythroid-derived 2)-like 2 (Nrf2)/Kelch-like erythroid-cell-derived protein with CNC homology-(ECH-) associated protein 1 (Keap1)/antioxidant response element (ARE) signaling is well known as one of the main antioxidative defense systems. To the best of our knowledge, this is the first review to elucidate the different expression profiles of Nrf2 signaling as well as the underlying mechanisms in corneal diseases, implicating that Nrf2 may serve as a potentially promising therapeutic target for corneal diseases.

引用

页数：9

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