Bromopyrrole Alkaloids from the Sponge Agelas kosrae

被引：12

作者：

Kwon, Oh-Seok ^{[1
]}

Kim, Donghwa ^{[1
]}

Kim, Heegyu ^{[2
]}

Lee, Yeon-Ju ^{[3
]}

Lee, Hyi-Seung ^{[3
]}

Sim, Chung J. ^{[4
]}

Oh, Dong-Chan ^{[1
]}

Lee, Sang Kook ^{[1
]}

Oh, Ki-Bong ^{[2
]}

Shin, Jongheon ^{[1
]}

机构：

[1] Seoul Natl Univ, Coll Pharm, Nat Prod Res Inst, San 56-1, Seoul 151742, South Korea

[2] Seoul Natl Univ, Coll Agr & Life Sci, Dept Agr Biotechnol, San 56-1, Seoul 151921, South Korea

[3] Korea Inst Ocean Sci & Technol, Marine Nat Prod Lab, POB 29, Seoul 425600, South Korea

[4] Hannam Univ, Coll Life Sci & Nano Technol, Dept Biol Sci, 461-6 Jeonmin, Yuseong 305811, Daejeon, South Korea

来源：

MARINE DRUGS | 2018年 / 16卷 / 12期

基金：

新加坡国家研究基金会;

关键词：

sceptrin; pyrrole-imidazole alkaloids; marine sponge; anti-angiogenesis; isocitrate lyase; bioactive marine natural products; MARINE; METABOLITES; HANISHIN; SCEPTRIN; OROIDIN;

D O I：

10.3390/md16120513

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two new sceptrin derivatives (1,2) and eight structurally-related known bromopyrrole-bearing alkaloids were isolated from the tropical sponge Agelas kosrae. By a combination of spectroscopic methods, the new compounds, designated dioxysceptrin (1) and ageleste C (2), were determined to be structural analogs of each other that differ at the imidazole moiety. Dioxysceptrin was also found to exist as a mixture of -amido epimers. The sceptrin alkaloids exhibited weak cytotoxicity against cancer cells. Compounds 1 and 2 also moderately exhibited anti-angiogenic and isocitrate lyase-inhibitory activities, respectively.

引用

页数：11

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