Transgenic farm animals: an update

被引：88
|
作者：
Niemann, Heiner [1 ]
Kues, Wilfried A. [1 ]
机构：
[1] Inst Anim Breeding, Dept Biotechnol, D-31535 Neustadt, Germany
来源：
REPRODUCTION FERTILITY AND DEVELOPMENT | 2007年 / 19卷 / 06期
关键词：
conditional transgene expression; gene pharming; lentiviral mediated transgenesis; pronuclear DNA injection; RNA interference; somatic cloning; xenotransplantation;
D O I：
10.1071/RD07040
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The first transgenic livestock species were reported in 1985. Since then microinjection of foreign DNA into pronuclei of zygotes has been the method of choice. It is now being replaced by more efficient protocols based on somatic nuclear transfer that also permit targeted genetic modifications. Lentiviral vectors and small interfering ribonucleic acid (siRNA) technology are also becoming important tools for transgenesis. In 2006 the European Medicines Agency (EMEA) gave green light for the commercialistion of the first recombinant protein produced in the milk of transgenic animals. Recombinant antithrombin III will be launched as ATryn for prophylactic treatment of patients with congenital antithrombin deficiency. This important milestone will boost the research activities in farm animal transgenesis. Recent developments in transgenic techniques of farm animals are discussed in this review.
引用
收藏
页码：762 / 770
页数：9
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