Propylphosphonic anhydride (T3P(R))-mediated three-component synthesis of hexahydrodibenzo[b,e][1,4]diazepin-1-one derivatives

被引：7
|
作者：
Hazai, Viktor [1 ]
Szabo, Timea [1 ]
Volk, Balazs [1 ]
Milen, Matyas [1 ]
机构：
[1] Egis Pharmaceut Plc, Directorate Drug Subst Dev, POB 100, H-1475 Budapest, Hungary
来源：
CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2020年 / 56卷 / 02期
关键词：
1; 5-benzodiazepines; nitrogen heterocycles; propylphosphonic anhydride (T3P(R)); three-component synthesis; ONE-POT; BENZODIAZEPINE DERIVATIVES; MULTICOMPONENT SYNTHESIS; ENVIRONMENTALLY BENIGN; EFFICIENT SYNTHESIS; CATALYST; 1,5-BENZODIAZEPINES; 1,4-BENZODIAZEPINES; NANOPARTICLES;
D O I：
10.1007/s10593-020-02650-3
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
In this work, the novel approach via propylphosphonic anhydride (T3P(R))-promoted synthesis of 1,5-benzodiazepines from o-phenylene-diamine, 5,5-dimethylcyclohexane-1,3-dione (dimedone), and aromatic aldehydes has been studied. The reaction conditions were optimized and the scope of the reaction was extended to various aromatic aldehydes. The synthesized compounds were obtained in reasonable to good yields.
引用
收藏
页码：237 / 240
页数：4
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