Extracellular Vesicles in Facial Aesthetics: A Review

被引:11
|
作者
Kee, Li Ting [1 ]
Ng, Chiew Yong [1 ]
Al-Masawa, Maimonah Eissa [1 ]
Foo, Jhi Biau [2 ,3 ]
How, Chee Wun [4 ]
Ng, Min Hwei [1 ]
Law, Jia Xian [1 ]
机构
[1] Univ Kebangsaan Malaysia, Fac Med, Ctr Tissue Engn & Regenerat Med, Jalan Yaacob Latif, Kuala Lumpur 56000, Malaysia
[2] Taylors Univ, Sch Pharm, Fac Hlth & Med Sci, Subang Jaya 47500, Malaysia
[3] Taylors Univ, Fac Hlth & Med Sci, Ctr Drug Discovery & Mol Pharmacol CDDMP, Subang Jaya 47500, Malaysia
[4] Monash Univ Malaysia, Sch Pharm, Bandar Sunway 47500, Malaysia
关键词
extracellular vesicle; cosmetic; skin rejuvenation; anti-aging; anti-scarring; pigmentation; MESENCHYMAL STEM-CELLS; DERMAL FIBROBLASTS; HYPERTROPHIC SCAR; GENE-EXPRESSION; EXOSOMES; SKIN; HYDROGEL; DELIVERY; COLLAGEN; ACTIVATION;
D O I
10.3390/ijms23126742
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Facial aesthetics involve the application of non-invasive or minimally invasive techniques to improve facial appearance. Currently, extracellular vesicles (EVs) are attracting much interest as nanocarriers in facial aesthetics due to their lipid bilayer membrane, nanosized dimensions, biological origin, intercellular communication ability, and capability to modulate the molecular activities of recipient cells that play important roles in skin rejuvenation. Therefore, EVs have been suggested to have therapeutic potential in improving skin conditions, and these highlighted the potential to develop EV-based cosmetic products. This review summarizes EVs' latest research, reporting applications in facial aesthetics, including scar removal, facial rejuvenation, anti-aging, and anti-pigmentation. This review also discussed the advanced delivery strategy of EVs, the therapeutic potential of plant EVs, and clinical studies using EVs to improve skin conditions. In summary, EV therapy reduces scarring, rejuvenates aging skin, and reduces pigmentation. These observations warrant the development of EV-based cosmetic products. However, more efforts are needed to establish a large-scale EV production platform that can consistently produce functional EVs and understand EVs' underlying mechanism of action to improve their efficacy.
引用
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页数:26
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