Cooperation between alteration of DNA gyrase genes and over-expression of MexB and MexX confers high-level fluoroquinolone resistance in Pseudomonas aeruginosa strains isolated from a patient who received a liver transplant followed by treatment with fluoroquinolones

被引：10

作者：

Niga, T

Ito, H

Oyamada, Y

Yamagishi, J

Kadono, M

Nishino, T

Gotoh, N

Inoue, M

机构：

[1] Dainippon Pharmaceut Co Ltd, Pharmacol & Microbiol Res Labs, Osaka 5640053, Japan

[2] Kyoto Pharmaceut Univ, Dept Microbiol, Kyoto 6078414, Japan

[3] Kitasato Univ, Sch Med, Dept Microbiol, Kanagawa 2288555, Japan

来源：

MICROBIOLOGY AND IMMUNOLOGY | 2005年 / 49卷 / 05期

关键词：

fluoroquinolone-resistance; Pseudomonas aeruginosa; DNA gyrase; efflux systems;

D O I：

10.1111/j.1348-0421.2005.tb03748.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Clinical isolates of highly fluoroquinolone-resistant Pseudomonas aeruginosa had a mutation in either A or B subunit of DNA gyrase and over-expressed MexB and MexX, the efflux system proteins. Introduction of wild-type gyrase genes of Escherichia coli into the isolates made them as fluoroquinolone-susceptible as the moderately fluoroquinolone-resistant strains that only over-expressed efflux system proteins. These findings demonstrate that high fluoroquinolone-resistance in P. aeruginosa is attributed to cooperation between alteration in DNA gyrase genes and over-expression of efflux systems proteins.

引用

页码：443 / 446

页数：4