Nickel/Copper Dual Catalysis for Sequential Nazarov Cyclization/Decarboxylative Aldol Reaction

被引：9
|
作者：
Zhang, Heyi [1 ]
Lu, Zhan [1 ]
机构：
[1] Zhejiang Univ, Dept Chem, 866 Yuhangtang Rd, Hangzhou 310058, Zhejiang, Peoples R China
来源：
ORGANIC LETTERS | 2018年 / 20卷 / 18期
基金：
中国国家自然科学基金;
关键词：
BETA-KETOACIDS; DECARBOXYLATIVE ADDITION; POLYKETIDE BIOSYNTHESIS; TRIFLUOROMETHYL KETONES; HALF THIOESTERS; CYCLIZATION; ACID; CYCLOPENTENONES; CONSTRUCTION; KETOESTERS;
D O I：
10.1021/acs.orglett.8b02426
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A nickel/copper cocatalyzed sequential Nazarov cyclization/decarboxylative aldol reaction is reported. Various beta-hydroxycyclopentenones containing three contiguous stereocenters were prepared in good yields with high diastereoselectivities. A gram-scale reaction and further derivatizations were easily achieved to highlight the synthetic utility of this transformation. Preliminary attempts for sequential asymmetric transformation were also conducted.
引用
收藏
页码：5709 / 5713
页数：5
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