Methamphetamine-induced Fos expression in the substantia nigra pars reticulata in rats with a unilateral 6-OHDA lesion of the nigrostriatal fibers

被引：5
|
作者：
Ishida, Y
Todaka, K
Kuwahara, I
Nakane, H
Ishizuka, Y
Nishimori, T
Mitsuyama, Y
机构：
[1] Miyazaki Med Coll, Dept Psychiat, Miyazaki 8891692, Japan
[2] Miyazaki Med Coll, Div Biol, Miyazaki 8891692, Japan
来源：
NEUROSCIENCE RESEARCH | 1998年 / 30卷 / 04期
关键词：
6-hydroxydopamine; methamphetamine; Fos; striatum; substantia nigra pars reticulata; rat;
D O I：
10.1016/S0168-0102(98)00015-7
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
In rats with a unilateral 6-hydroxydopamine (6-OHDA)-induced lesion in the nigrostriatal fibers, methamphetamine (3 mg/kg, i.p.) induced Fos-like immunoreactivity (FLI), which was inhibited by pretreatment with N-methyl-D-aspartate antagonist MK-801 (1 mg/kg, i.p.), not only in the medial striatum contraiateral to the lesion but also in the substantia nigra pars reticulata (SNr) ipsilateral to the lesion. Thus, hemispheric asymmetries in FLI were induced by methamphetamine in the medial striatum and the SNr in the 6-OHDA model of turning which may be related to the altered function of glutamatergic transmission. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.
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页码：355 / 360
页数：6
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