Preliminary Study of the Impact of Single-Nucleotide Polymorphisms ofIL-1α,IL-1βandTNF-αGenes on the Occurrence, Severity and Treatment Effectiveness of the Major Depressive Disorder

被引：8
|
作者：
Bialek, Katarzyna [1 ]
Czarny, Piotr [2 ]
Watala, Cezary [3 ]
Synowiec, Ewelina [1 ]
Wigner, Paulina [1 ]
Bijak, Michal [4 ]
Talarowska, Monika [5 ]
Galecki, Piotr [6 ]
Szemraj, Janusz [2 ]
Sliwinski, Tomasz [1 ]
机构：
[1] Univ Lodz, Fac Biol & Environm Protect, Lab Med Genet, 141-143 Pomorska St, PL-90236 Lodz, Poland
[2] Med Univ Lodz, Dept Med Biochem, Lodz, Poland
[3] Med Univ Lodz, Dept Haemostat Disorders, Lodz, Poland
[4] Univ Lodz, Fac Biol & Environm Protect, Biohazard Prevent Ctr, Lodz, Poland
[5] Univ Lodz, Inst Psychol, Dept Personal & Individual Differences, Lodz, Poland
[6] Med Univ Lodz, Dept Adult Psychiat, Lodz, Poland
来源：
CELLULAR AND MOLECULAR NEUROBIOLOGY | 2020年 / 40卷 / 06期
关键词：
Major depressive disorder; Inflammation; Single nucleotide polymorphism; Cytokine; RISK;
D O I：
10.1007/s10571-019-00782-5
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The purpose of the preliminary study was to determine whether the occurrence of certain SNPs of genes encodingIL-1 alpha,IL-1 beta, andTNF-alpha is associated with the development of depression. Five polymorphisms were selected: i.e. c.-1560G > C-IL-1 beta(rs1143623), c. -118 C > T-IL-1 beta(rs1143627), c.340G > T-IL-1 alpha(rs17561), c.-1211T > C-TNF-alpha(rs1799964) and c.-488G > A-TNF-alpha(rs1800629). These were analyzed using TaqMan probes. The genotypes of the analyzed polymorphisms were found to be associated with disease severity and may affect the effectiveness of antidepressant therapy. In addition, the gene-gene analysis confirmed that combined genotypes of investigated SNPs may modulate the risk of depression.
引用
收藏
页码：1049 / 1056
页数：8
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