Resolution of Propranolol and Atenolol Enantiomers on β-Cyclodextrin-Impregnated Silica Gel Layers

被引：3
|
作者：
Joshi, S. [1 ]
Sharma, A. [2 ]
机构：
[1] Doon Univ, Sch Environm & Nat Resources, Dept Environm Studies, Dehra Dun 248001, Uttar Pradesh, India
[2] KLDAV PG Coll, Dept Chem, Roorkee 247667, Uttar Pradesh, India
来源：
ACTA CHROMATOGRAPHICA | 2012年 / 24卷 / 02期
关键词：
beta-blocker drugs; enantiomeric resolution; beta-cyclodextrin; impregnated silica gel plates; iodine vapor detection; CHIRAL STATIONARY-PHASE; ADRENERGIC BLOCKING-AGENTS; LIQUID-CHROMATOGRAPHY; TLC RESOLUTION; SEPARATION; BLOCKERS; ACID; ENANTIOSEPARATION; COMPLEXATION; DERIVATIVES;
D O I：
10.1556/AChrom.24.2012.2.13
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Enantiomeric resolution of two commonly used beta-blockers, namely, (+/-)-propranolol and (+/-)-atenolol, has been achieved on silica gel layers which were bulk-impregnated with beta-cyclodextrin. Solvent systems DMF-ethyl acetate-butanol (3:2:5, v/v) and butanol-acetic acid-thyl acetate-ammonia (5:2:2:0.5, v/v) successfully resolved the enantiomers of (+/-)-propranolol and (+/-)-atenolol, respectively. The spots were located with iodine vapor. The effects of concentration of the chiral selector and mobile phase variation were also studied.
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页码：317 / 322
页数：6
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