Norbisabolane-type sesquiterpenoid derivatives, benzofuran lignans and a phenolic glycoside from the roots of Glochidion wilsonii Hutch

被引：3

作者：

Gao, Ruixi ^{[1
]}

Xu, Xuan ^{[2
]}

Sun, Hao ^{[1
]}

Cao, Zhijian ^{[1
]}

Chen, Rui ^{[1
]}

Zeng, Xiaomei ^{[1
]}

Chen, Faju ^{[3
]}

Liao, Maochuan ^{[4
]}

Li, Jun ^{[4
]}

Liu, Jing Yu ^{[2
]}

机构：

[1] Huazhong Univ Sci & Technol, Coll Life Sci & Technol, Wuhan 430074, Peoples R China

[2] Chinese Acad Sci, Inst Neurosci, Ctr Excellence Brain Sci & Intelligence Technol, State Key Lab Neurosci, Shanghai 200031, Peoples R China

[3] Three Gorges Univ, Ctr Biotechnol Res China, Key Lab Plant Genet & Germplasm Innovat Three Gorg, Yichang 443002, Hubei, Peoples R China

[4] South Cent Univ Nationalities, Sch Pharm, Wuhan 430074, Peoples R China

来源：

PHYTOCHEMISTRY | 2022年 / 204卷

关键词：

Glochidion wilsonii Hutch; Euphorbiaceae; Norbisabolane-type sesquiterpenoid glycoside; Benzofuran lignan; Phenolic glycoside; Structure elucidation; Chemotaxonomic significance; CHEMICAL-CONSTITUENTS; DIHYDROBENZOFURAN LIGNAN; ABSOLUTE-CONFIGURATIONS; LUPANE TRITERPENOIDS; HONG-KONG; A-D; LEAVES; GLUCOSIDES; NEOLIGNANS; PHENYLPROPANOIDS;

D O I：

10.1016/j.phytochem.2022.113447

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Three highly oxygenated norbisabolane sesquiterpenoid glycosides (glochiwilsonosides A-C), five benzofuran lignans (glochiwilsonises A-E) and a phenolic glycoside (glochiwilsophe-noside), together with forty-one known compounds, were isolated from the roots of Glochidion wilsonii Hutch. The chemical structures of the compounds were identified by spectroscopic methods and previous literature data. Glochiwilsonoside A displayed anti -proliferative activity on A-549 and RAW 264.7 cell lines with an IC50 value of 34.5 +/- 0.9 mu M and CC50 value of 16.0 +/- 0.9 mu M, respectively. Twenty-three known compounds were reported from the genus Glochidion for the first time, and the chemotaxonomic characteristics of the isolated compounds were also summarized. The bisabolane/norbisabolane-type sesqui-terpenoid derivatives could be used as chemotaxonomic markers for G. wilsonii.

引用

页数：12