Control of incomplete separation in simulated moving bed chromatographic processes

被引：6

作者：

Suvarov, Paul ^{[1
]}

Vande Wouwer, Alain ^{[1
]}

Lee, Ju Weon ^{[2
]}

Seidel-Morgensten, Andreas ^{[2
]}

Kienle, Achim ^{[2
]}

机构：

[1] Univ Mons UMONS, Serv Automat, B-7000 Mons, Belgium

[2] Max Planck Inst Dynam Komplexer Tech Syst, D-39106 Magdeburg, Germany

来源：

IFAC PAPERSONLINE | 2016年 / 49卷 / 07期

关键词：

chromatography; process control; adaptive control; parameter estimation; FEED CONCENTRATION; CYCLIC MODULATION; OPTIMAL OPERATION; ADAPTIVE-CONTROL;

D O I：

10.1016/j.ifacol.2016.07.232

中图分类号：

TP [自动化技术、计算机技术];

学科分类号：

0812 ;

摘要：

Simulated moving bed (SMB) is a continuous chromatographic process used for the separation of fluid mixtures. This paper presents a simple control strategy to handle incomplete separation; which requires tight control to achieve the desired purities. At first, a discrete-time nonlinear model is derived from wave theorif. which will be the basis to estimate the position of the adsorption and desorption fronts. Four controllers are designed. two for the position of the concentration waves in zone 1 and 4. and two for the purities at the extract and raffinate outlets. The performance of the control strategy is evaluated with an experimental study of the separation of racemic Bicalutamide enantiomers in a 4 column-SMB. (C) 2016, IFAC (International Federation of Automatic Control) Hosting by Elsevier Ltd. All rights reserved.

引用

页码：153 / 158

页数：6

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