Immune-Related Adverse Events Associated with Immune Checkpoint Inhibitors

被引：78
|
作者：
Day, Daphne [1 ,2 ,3 ]
Hansen, Aaron R. [1 ,2 ]
机构：
[1] Princess Margaret Canc Ctr, Bras Drug Dev Program, Div Med Oncol & Hematol, 610 Univ Ave,Suite, Toronto, ON M5G 2M9, Canada
[2] Univ Toronto, Dept Med, Toronto, ON, Canada
[3] Ontario Inst Canc Res, OICR Res Fellow, 661 Univ Ave,Suite 510, Toronto, ON M5G 0A3, Canada
来源：
BIODRUGS | 2016年 / 30卷 / 06期
关键词：
PRETREATED ADVANCED MELANOMA; RESISTANT PROSTATE-CANCER; METASTATIC MELANOMA; OPEN-LABEL; DOUBLE-BLIND; PATIENTS PTS; PHASE-I; ANTI-CTLA-4; ANTIBODY; ANTI-PD-L1; NIVOLUMAB ANTI-PD-1;
D O I：
10.1007/s40259-016-0204-3
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Immune checkpoint inhibitors (ICIs), including antibodies targeting cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) and programmed cell death protein-1 (PD-1), have shown durable treatment responses in multiple tumor types by enhancing antitumor immunity. However, removal of self-tolerance can induce autoimmunity and produce a unique immune-driven toxicity profile, termed immune-related adverse events (irAEs). As ICIs gain approval for a growing number of indications, it is imperative clinicians increase their knowledge of and ability to manage irAEs. This review examines the etiology, presentation, kinetics, and treatment of irAEs and aims to provide practical guidance for clinicians.
引用
收藏
页码：571 / 584
页数：14
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