An Efficient One-Pot Three-Component Reaction for Synthesis of Spirooxindole Derivatives in Water Media under Catalyst-Free Condition

被引：35
|
作者：
Zhao, Liqin [1 ]
Zhou, Bo [1 ]
Li, Yiqun [1 ]
机构：
[1] Jinan Univ, Dept Chem, Guangzhou 510632, Guangdong, Peoples R China
来源：
HETEROATOM CHEMISTRY | 2011年 / 22卷 / 05期
基金：
中国国家自然科学基金;
关键词：
SOLVENT-FREE CONDITION; MULTICOMPONENT REACTIONS; AQUEOUS-MEDIUM; MALONONITRILE; INHIBITORS; ISATINS; FACILE;
D O I：
10.1002/hc.20723
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An efficient, clean, and environmentally benign synthesis of spirooxindole derivatives by one-pot three-component reaction of isatins, malononitrile, and carbonyl compound in the absence of catalysis in water was described. A variety of spirooxindole derivatives were obtained with excellent yields within short reaction time. This novel protocol has the advantages of convenient operation, low cost, and environmental benign. (C) 2011 Wiley Periodicals, Inc. Heteroatom Chem 22:673-677, 2011; View this article online at wileyonlinelibrary.com. DOI 10.1002/hc.20723
引用
收藏
页码：673 / 677
页数：5
相关论文
共 50 条
  • [1] Efficient Catalyst-Free One-Pot Three-Component Synthesis of Novel Spirooxindole Derivatives, and Their Cytotoxic Activities
    Han, Chao
    Zhang, Tao
    Zhang, Anqi
    Wang, Dandan
    Shi, Weimin
    Tao, Jingchao
    [J]. SYNTHESIS-STUTTGART, 2014, 46 (10): : 1389 - 1398
  • [2] An Efficient Three-component, One-pot Synthesis of Quinazolines under Solvent-free and Catalyst-free Condition
    Bhat, Subrahmanya Ishwar
    Das, U. K.
    Trivedi, Darshak R.
    [J]. JOURNAL OF HETEROCYCLIC CHEMISTRY, 2015, 52 (04) : 1253 - 1259
  • [3] One-Pot and Three-Component Synthesis of Furopyridoquinoxaline Derivatives under Catalyst-Free Conditions
    Zhang, Meimei
    Wang, Jie
    Liu, Jianquan
    Wang, Xiangshan
    [J]. CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2017, 37 (06) : 1565 - 1570
  • [4] Efficient catalyst-free synthesis of diversified bis (spirooxindoles) via one-pot, three-component reaction
    Khanna, Garima
    Aggarwal, Komal
    Khurana, Jitender M.
    [J]. SYNTHETIC COMMUNICATIONS, 2016, 46 (23) : 1880 - 1886
  • [5] Efficient One-Pot Synthesis of Novell Spirooxindole Derivatives via Three-Component Reaction in Aqueous Medium
    Chen, Hui
    Shi, Daqing
    [J]. JOURNAL OF COMBINATORIAL CHEMISTRY, 2010, 12 (04): : 571 - 576
  • [6] Visible light-induced one-pot three-component synthesis of quinazolines under catalyst-free condition
    Ma, Xue
    Chen, Xuerou
    Ying, Letian
    Pang, Yuqi
    Zhong, Qidi
    Li, Dongmei
    Sun, Wuji
    [J]. MOLECULAR CATALYSIS, 2023, 546
  • [7] Catalyst-free one-pot synthesis of isoindolin-1-imine derivatives via three-component reaction
    Shen, Sida
    Pham Van Khang
    Chen, Yijia
    Lei, Min
    Hu, Lihong
    [J]. ARKIVOC, 2013, : 413 - 423
  • [8] A one-pot three-component synthesis of novel α-sulfamidophosphonates under ultrasound irradiation and catalyst-free conditions
    Belhani, Billel
    Berredjem, Malika
    Le Borgne, Marc
    Bouaziz, Zouhair
    Lebreton, Jacques
    Aouf, Nour-Eddine
    [J]. RSC ADVANCES, 2015, 5 (49) : 39324 - 39329
  • [9] Catalyst-Free, One-Pot, Three-Component Synthesis of 3-Arylsulfonylated Thioflavones
    Bhat, Vighneshwar Shridhar
    Lee, Anna
    [J]. ADVANCED SYNTHESIS & CATALYSIS, 2022, 364 (17) : 3088 - 3093
  • [10] Efficient One-Pot Synthesis of Novel Spirooxindole-Fused Phosphorous Heterocycle Derivatives by a Three-Component Domino Reaction
    Liu, Rendie
    Wu, Mingshu
    Li, Guozhu
    [J]. HETEROATOM CHEMISTRY, 2014, 25 (03) : 140 - 146
12345