Direct and indirect P-glycoprotein transfers in MCF7 breast cancer cells

被引：2
|
作者：
Dyson, Janet [1 ]
Le Foll, Frank [2 ]
Magal, Pierre [3 ,4 ]
Noussair, Ahmed [3 ,4 ]
Pasquier, Jennifer [5 ,6 ]
机构：
[1] Univ Oxford, Math Inst, Oxford, England
[2] Univ Le Havre, Lab Ecotoxicol, F-76058 Le Havre, France
[3] Univ Bordeaux, IMB, UMR 5251, F-33400 Talence, France
[4] CNRS, IMB, UMR 5251, F-33400 Talence, France
[5] Qatar Fdn, Stem Cell & Microenvironm Lab, Weill Cornell Med Coll Qatar, Educ City, PO 24144, Doha, Qatar
[6] Weill Cornell Med Coll, Dept Genet Med, New York, NY USA
来源：
JOURNAL OF THEORETICAL BIOLOGY | 2019年 / 461卷
关键词：
Indirect transfers; Kinetic; Quasi-linear equation; Population dynamics models; INTERCELLULAR TRANSFER; MULTIDRUG-RESISTANCE; DRUG; MODEL;
D O I：
10.1016/j.jtbi.2018.10.040
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The efflux protein P-glycoprotein (P-gp) is over expressed in many cancer cells and has a known capacity to confer multi-drug resistance to cytotoxic therapies. We provide a mathematical model for the direct cell-to-cell transfer of proteins between cells and the indirect transfer between cells and the surrounding liquid. After a mathematical analysis of the model, we construct an adapted numerical scheme and give some numerical simulations. We observe that we obtain a better fit with the experimental data when we take into account the indirect transfer of the protein released in a dish. This quantity, usually neglected by the experimenters, seems to influence the results. (C) 2018 Elsevier Ltd. All rights reserved.
引用
收藏
页码：239 / 253
页数：15
相关论文
共 50 条
  • [1] Polyprenol could inhibit P-glycoprotein in human MCF-7 breast cancer cells
    Kuznecovs, I.
    [J]. ANNALS OF ONCOLOGY, 2007, 18 : 37 - 37
  • [2] Different Modalities of Intercellular Membrane Exchanges Mediate Cell-to-cell P-glycoprotein Transfers in MCF-7 Breast Cancer Cells
    Pasquier, Jennifer
    Galas, Ludovic
    Boulange-Lecomte, Celine
    Rioult, Damien
    Bultelle, Florence
    Magal, Pierre
    Webb, Glenn
    Le Foll, Frank
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 287 (10) : 7374 - 7387
  • [3] Pegylated Phosphotidylethanolamine Inhibiting P-Glycoprotein Expression and Enhancing Retention of Doxorubicin in MCF7/ADR Cells
    Wang, Jing
    Qu, Hui
    Jin, Lingtao
    Zeng, Wenfeng
    Qin, Lei
    Zhang, Fayun
    Wei, Xiuli
    Lu, Wanliang
    Zhang, Chunling
    Liang, Wei
    [J]. JOURNAL OF PHARMACEUTICAL SCIENCES, 2011, 100 (06) : 2267 - 2277
  • [4] REIC/Dkk-3 overexpression downregulates P-glycoprotein in multidrug-resistant MCF7/ADR cells and induces apoptosis in breast cancer
    K Kawasaki
    M Watanabe
    M Sakaguchi
    Y Ogasawara
    K Ochiai
    Y Nasu
    H Doihara
    Y Kashiwakura
    N-h Huh
    H Kumon
    H Date
    [J]. Cancer Gene Therapy, 2009, 16 : 65 - 72
  • [5] REIC/Dkk-3 overexpression downregulates P-glycoprotein in multidrug-resistant MCF7/ADR cells and induces apoptosis in breast cancer
    Kawasaki, K.
    Watanabe, M.
    Sakaguchi, M.
    Ogasawara, Y.
    Ochiai, K.
    Nasu, Y.
    Doihara, H.
    Kashiwakura, Y.
    Huh, N-h
    Kumon, H.
    Date, H.
    [J]. CANCER GENE THERAPY, 2009, 16 (01) : 65 - 72
  • [6] Differential modulation by estradiol of P-glycoprotein drug resistance protein expression in cultured MCF7 and T47D breast cancer cells
    Zampieri, L
    Bianchi, P
    Ruff, P
    Arbuthnot, P
    [J]. ANTICANCER RESEARCH, 2002, 22 (04) : 2253 - 2259
  • [7] p-Hydroxybenzoate esters metabolism in MCF7 breast cancer cells
    Dagher, Zeina
    Borgie, Mireille
    Magdalou, Jacques
    Chahine, Ramez
    Greige-Gerges, Helene
    [J]. FOOD AND CHEMICAL TOXICOLOGY, 2012, 50 (11) : 4109 - 4114
  • [8] Dolichyl phosphate dependent P-glycoprotein expression in Doxorubicin resistant MCF-7 breast cancer cells
    Kuznecovs, I.
    Kuznecovs, S.
    Jegina, K.
    Kuznecova, G.
    [J]. EJC SUPPLEMENTS, 2008, 6 (09): : 86 - 86
  • [9] Dolichyl phosphate and polyprenol could inhibit P-glycoprotein in human MCF-7 breast cancer cells
    Kuznecovs, I.
    Jegina, K.
    Kuznecovs, S.
    [J]. EJC SUPPLEMENTS, 2008, 6 (07): : 100 - 100
  • [10] EFFECT OF P-GLYCOPROTEIN EXPRESSION ON SENSITIVITY TO HORMONES IN MCF-7 HUMAN BREAST-CANCER CELLS
    CLARKE, R
    CURRIER, S
    KAPLAN, O
    LOVELACE, E
    BOULAY, V
    GOTTESMAN, MM
    DICKSON, RB
    [J]. JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1992, 84 (19) : 1506 - 1512
12345