Poly(ethylene glycol) (PEG) as a new phase-transfer catalyst in the palladium-catalyzed Heck reaction:: positive effect of the polymer in the supported synthesis of α-aminoesters

被引：8
|
作者：
Sauvagnat, B
Lamaty, F
Lazaro, R
Martinez, J
机构：
[1] Univ Montpellier I, CNRS, Lab Aminoacides Peptides & Prot, F-34095 Montpellier 5, France
[2] Univ Montpellier 2, CNRS, Lab Aminoacides Peptides & Prot, F-34095 Montpellier 5, France
来源：
COMPTES RENDUS DE L ACADEMIE DES SCIENCES SERIE II FASCICULE C-CHIMIE | 1998年 / 1卷 / 12期
关键词：
Heck reaction; solid-liquid phase-transfer catalysis; palladium; poly(ethylene glycol) (PEG); soluble polymer supported synthesis; glutamic acid;
D O I：
10.1016/S1251-8069(99)80045-0
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A poly(ethylene glycol) (PEG) supported substrate bearing a methyl acrylate moiety has been subjected to a palladium-catalyzed Heck reaction with phenyl iodide to afford an analogue of glutamic acid with a good regio- and stereoselectivity of the double bond. It was found that PEG (present in the starting material) acts as a phase-transfer catalyst as well as polymer support. No further catalyst such as a quaternary ammonium salt is required in this reaction. (C) Academie des sciences/Elsevier, Paris.
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页码：777 / 780
页数：4
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