Paraneoplastic Syndrome in Haemophagocytic Histiocytic Sarcoma in a Dog

被引:18
|
作者
Soare, T. [1 ,2 ]
Noble, P. -J. [3 ]
Hetzel, U. [1 ]
Fonfara, S. [3 ]
Kipar, A. [1 ]
机构
[1] Univ Liverpool, Sch Vet Sci, Dept Vet Pathol, Liverpool L69 7ZJ, Merseyside, England
[2] Univ Agr Sci & Vet Med, Bucharest 050097, Romania
[3] Univ Liverpool, Small Anim Teaching Hosp, Sch Vet Sci, Neston CH64 7TE, England
关键词
haemophagocytic histiocytic sarcoma; IL-6; phagocytosis; spleen; GENE-EXPRESSION; SPLEEN; ALBUMIN; CELLS; INTERLEUKIN-6; DEGRADATION; CYTOKINES; MARKERS; TISSUE; FEVER;
D O I
10.1016/j.jcpa.2011.05.006
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
A case of metastatic splenic haemophagocytic histiocytic sarcoma (HHS) in a 6-year-old neutered male flat-coated retriever is described. The main clinical findings were hypoalbuminaemia and regenerative anaemia. The diagnosis was based on histological features and expression of CD11d by the neoplastic cells. Tumour cells were shown to produce interleukin (IL)-6, to phagocytose erythrocytes and to take up albumin, as demonstrated by immunohistochemistry and ultrastructural examination. Quantitative polymerase chain reaction identified increased IL-6 gene expression in affected organs. These findings suggest that neoplastic cells are responsible for the clinical features of HHS, by removing erythrocytes and albumin from the blood and releasing cytokines, such as IL-6. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码:168 / 174
页数:7
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