FORMULATION AND CHARACTERIZATION OF SELF EMULSIFYING DRUG DELIVERY SYSTEM (SEDDS) FOR SOLUBILITY ENHANCEMENT OF POORLY WATER SOLUBLE DRUG

The current study is done for formulating and characterizing self-emulsifying drug delivery system (SEDDS). In the current research it has been shown that the SEDDS is a tedious pharmaceutical technology which has the potential for the improvement in biopharmaceutics properties like absorption, metabolism, distribution and excretion of Cyclosporin A also opens new window for developing the procedures to enhance the solubility of low water solubilised drugs. The stability in gastrointestinal drug as well as rate of absorption of drug in SEDDS can be increased by this approach. 3 types of methods were used for the formulation of Self emulsifying drug delivery system (SEDDS) containing cyclosporine: Cold homogenisation method, Hot Homogenisation method and method of injection with the use of emulsifying agent and stabilising agent.The optimisation of formulation variables were done with the use of 33 factorial design. The analysation of 3 independent formulation variables were done at the time of study which includes the concentration of surfactant (A), concentration of stabiliser (B) and lipid concentration (C). The droplet size (X) and polydispersity index (Y) were the investigated dependent variables .The complete experiment includes 27 designed points. The pattern of release of optimized formulation was almost similar to the release pattern of marketed formulation. Less nephrotoxicity and less inflammation is observed in SEDDS containing Cyclosporin A when compared with available marketed product. Hence, SEDDS containing Cyclosporin A is a system which is very important for the enhancement of solubility of drugs which have very less solubility in water.