Neuropsychological Predictors of the Clinical Response to Cognitive-Behavioral Therapy in Patients with Major Depression

被引：20
|
作者：
Kundermann, Bernd [1 ,2 ]
Hemmeter-Spernal, Julia [2 ,3 ]
Strate, Peter [2 ,4 ]
Gebhardt, Stefan [2 ,5 ]
Huber, Martin Tobias [2 ,6 ]
Krieg, Juergen-Christian [2 ]
Lautenbacher, Stefan [7 ]
机构：
[1] Vitos Clin Psychiat & Psychotherapy Giessen, Giessen, Germany
[2] Univ Marburg, Dept Psychiat & Psychotherapy, D-35032 Marburg, Germany
[3] Psychiat Serv Canton St Gallen, Wil, Switzerland
[4] Private Hosp Psychiat & Psychotherapy, Cliena Schloessli, Oetwil Am See, Switzerland
[5] Psychiat Ctr Nordbaden, Dept Gen Psychiat Psychotherapy & Psychosomat 2, Wiesloch, Germany
[6] Hosp Stade, Dept Psychiat Psychotherapy & Psychosomat, Stade, Germany
[7] Univ Bamberg, Physiol Psychol, Bamberg, Germany
来源：
ZEITSCHRIFT FUR NEUROPSYCHOLOGIE | 2015年 / 26卷 / 02期
关键词：
depression; cognitive-behavioral therapy; neuropsychology; SLEEP-DEPRIVATION; VERBAL MEMORY; EXECUTIVE DYSFUNCTION; IMPAIRMENT; NONRESPONSE; EFFICACY; MODERATE; OUTCOMES; TRIAL; MOOD;
D O I：
10.1024/1016-264X/a000130
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Aim of the study was to identify neuropsychological predictors of the clinical response to cognitive behavioral therapy (CBT) in patients with major depression. 19 unmcdicated patients underwent neuropsychological testing at baseline and subsequently were assigned randomly to CBT over 3 weeks either as monotherapy or combined with sleep deprivation (SD) therapy (two nights of total SD / week). Hierarchical regression analysis revealed that parameters of declarative verbal memory and a word fluency task predicted the clinical response (percentage improvement of Hamilton depression scores) to CBT monotherapy, whereas no such prediction was obtained in the combination group. The results suggest that certain cognitive performances have a unique predictive value for the response to CBT, which appears to be abolished by additive treatments with cognitive side effects (e.g. SD).
引用
收藏
页码：87 / 97
页数：11
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