Synthesis and In Vitro Protein Tyrosine Kinase Inhibitory Activity of Furan-2-yl(phenyl)methanone Derivatives

被引：13

作者：

Zheng, Fei Lang ^{[1
]}

Ban, Shu Rong ^{[1
]}

Feng, Xiu E. ^{[1
]}

Zhao, Cheng Xiao ^{[1
]}

Lin, Wenhan ^{[2
]}

Li, Qing Shan ^{[1
,2
]}

机构：

[1] Shanxi Med Univ, Sch Pharmaceut Sci, Taiyuan 030001, Shanxi, Peoples R China

[2] Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China

来源：

MOLECULES | 2011年 / 16卷 / 06期

关键词：

halophenols; furan-2-yl(phenyl)methanone; protein tyrosine kinases inhibitor; structure-activity relationships (SAR); ANTIMICROBIAL ACTIVITIES; BROMOPHENOLS; DESIGN;

D O I：

10.3390/molecules16064897

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of novel furan-2-yl(phenyl) methanone derivatives were synthesized, and their structures were established on the basis of H-1-NMR, C-13-NMR and mass spectral data. All the prepared compounds were screened for their in vitro protein tyrosine kinase inhibitory activity and several new derivatives exhibited promising activity, which, in some cases, was identical to, or even better than that of genistein, a positive reference compound. The preliminary structure-activity relationships of these compounds were investigated and are discussed.

引用

页码：4897 / 4911

页数：15

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