Synthesis of novel alkyltriazole tagged pyrido[2,3-d]pyrimidine derivatives and their anticancer activity

被引：88

作者：

Kurumurthy, C. ^{[1
]}

Rao, P. Sambasiva ^{[1
]}

Swamy, B. Veera ^{[1
]}

Kumar, G. Santhosh ^{[1
]}

Rao, P. Shanthan ^{[1
]}

Narsaiah, B. ^{[1
]}

Velatooru, L. R. ^{[2
]}

Pamanji, R. ^{[2
]}

Rao, J. Venkateswara ^{[2
]}

机构：

[1] Indian Inst Chem Technol, Fluoroorgan Div, Hyderabad 500607, Andhra Pradesh, India

[2] Indian Inst Chem Technol, Div Biol, Hyderabad 500607, Andhra Pradesh, India

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2011年 / 46卷 / 08期

关键词：

Pyrido[2,3-d]pyrimidine; Cyclisation; Propargylation; Perfluoroalkyl azides; Sharpless conditions; Anticancer activity; BIOLOGICAL EVALUATION;

D O I：

10.1016/j.ejmech.2011.05.011

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of novel alkyltriazole tagged pyrido[2,3-d]pyrimidine derivatives 5 and 6 was prepared starting from 2,3-active functional pyridine 1 via cyclization, propargylation followed by reaction with alkyl or perfluoroalkyl azides under Sharpless conditions. All the compounds 5 and 6 were screened for anticancer activity against three cancer cell lines such as U-937, THP-1 and Colo205. The promising compounds 5b and Se have been identified. (C) 2011 Elsevier Masson SAS. All rights reserved.

引用

页码：3462 / 3468

页数：7

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