Targeting tumor-associated myeloid cells for cancer immunotherapy

被引：9

作者：

Qin, Hong ^{[1
,2
]}

Wei, Guowei ^{[1
,2
]}

Gwak, Dongho ^{[1
,2
]}

Dong, Zhenyuan ^{[1
,2
]}

Xiong, Ailian ^{[1
,2
]}

Kwak, Larry W. ^{[1
,2
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Lymphoma & Myeloma, Houston, TX 77030 USA

[2] Univ Texas MD Anderson Canc Ctr, Ctr Canc Immunol Res, Houston, TX 77030 USA

来源：

ONCOIMMUNOLOGY | 2015年 / 4卷 / 03期

关键词：

myeloid-derived suppressor cells; peptibody; tumor microenvironment; immunotherapy; immunosuppression; SUPPRESSOR-CELLS; FOLLICULAR LYMPHOMA; VACCINATION; SURVIVAL;

D O I：

10.4161/2162402X.2014.983761

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Tumor-associated myeloid cells undermine the therapeutic efficacy of cancer immunotherapy by their inhibitory properties on immune effector cells. Development of therapeutic agents to deplete suppressive myeloid cells in tumor microenvironment requires identification of cell-specific targets. A competitive phage display technique on live cells paves the way to discovery of such a target.

引用

页码：1 / 3

页数：3

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