Monoamine transporter and enzyme expression in the medial temporal lobe and frontal cortex following chronic bilateral vestibular loss

被引：44
|
作者：
Goddard, Matthew [1 ]
Zheng, Yiwen [1 ]
Darlington, Cynthia L. [1 ]
Smith, Paul F. [1 ]
机构：
[1] Univ Otago, Sch Med Sci, Dept Pharmacol & Toxicol, Dunedin, New Zealand
来源：
NEUROSCIENCE LETTERS | 2008年 / 437卷 / 02期
关键词：
bilateral vestibular deafferentation; medical temporal lobe; serotonin transporter; dopamine transporter; tyrosine hydroxylase; tryptophan hydroxylase; dopamine hydroxylase;
D O I：
10.1016/j.neulet.2008.03.073
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Peripheral vestibular damage has been reported to be associated with a high incidence of anxiety disorders and depression. In this study we investigated whether chronic bilateral vestibular deafferentation (BVD) would affect the expression of several biogenic amine enzymes and transporters in the medial temporal lobe (CA1, CA2/3, dentate gyrus (DG), entorhinal (EC) and perirhinal cortices (PRC)) and frontal lobes (FL) of rats. BVD was not associated with any significant differences in dopamine beta-hydroxylase or the dopamine transporter in any brain region studied. There was a significant decrease in tyrosine hydroxylase expression only in the FL and a significant decrease in the expression of the serotonin transporter in the FL and CA1 in BVD Fats. Tryptophan hydroxlase showed a significant increase in expression in the FL, CA2/3, and DG and a significant decrease in the EC. These results suggest that biogenic amine pathways in the medial temporal lobe and FL undergo changes following BVD. (c) 2008 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：107 / 110
页数：4
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  • [1] Synaptic protein expression in the medial temporal lobe and frontal cortex following chronic bilateral vestibular loss
    Goddard, Matthew
    Zheng, Yiwen
    Darlington, Cynthia L.
    Smith, Paul F.
    [J]. HIPPOCAMPUS, 2008, 18 (05) : 440 - 444
  • [2] Autobiographical memory of the recent past following frontal cortex or medial temporal lobe excisions
    Thaiss, L.
    Petrides, M.
    [J]. ARCHIVES OF CLINICAL NEUROPSYCHOLOGY, 2007, 22 (07) : 865 - 865
  • [3] Functions of ventral visual cortex after bilateral medial temporal lobe damage
    Kim, Jiye G.
    Gregory, Emma
    Landau, Barbara
    McCloskey, Michael
    Turk-Browne, Nicholas B.
    Kastner, Sabine
    [J]. PROGRESS IN NEUROBIOLOGY, 2020, 191
  • [4] Abnormal expression of serotonin transporter mRNA in the frontal and temporal cortex of schizophrenics
    I Hernandez
    B P Sokolov
    [J]. Molecular Psychiatry, 1997, 2 : 57 - 64
  • [5] Abnormal expression of serotonin transporter mRNA in the frontal and temporal cortex of schizophrenics
    Hernandez, I
    Sokolov, BP
    [J]. MOLECULAR PSYCHIATRY, 1997, 2 (01) : 57 - 64
  • [6] Persistent Neuronal Activity in Medial Temporal Lobe and Medial Frontal Cortex Supports Short-Term Memory
    Kaminski, Jan
    Sullivan, Shannon
    Chung, Jeffrey
    Ross, Ian
    Mamelak, Adam
    Rutishauser, Ueli
    [J]. JOURNAL OF NEUROSURGERY, 2017, 126 (04) : A1442 - A1443
  • [7] Early volumetric changes of hippocampus and medial prefrontal cortex following medial temporal lobe resection
    Pajkert, Anna
    Ploner, Christoph J.
    Lehmann, Thomas-Nicolas
    Witte, Veronica A.
    Oltmanns, Frank
    Sommer, Werner
    Holtkamp, Martin
    Heekeren, Hauke R.
    Finke, Carsten
    [J]. EUROPEAN JOURNAL OF NEUROSCIENCE, 2020, 52 (10) : 4375 - 4384
  • [8] Autobiographical memory of the recent past following frontal cortex or temporal lobe excisions
    Thaiss, Laila
    Petrides, Michael
    [J]. EUROPEAN JOURNAL OF NEUROSCIENCE, 2008, 28 (04) : 829 - 840
  • [9] Comparison of bold signal changes in the frontal cortex and the hippocampus in patients with medial temporal lobe epilepsy
    Wagner, K.
    Frings, L.
    Härle, M.
    Schwarzwald, R.
    Spreer, J.
    Halsband, U.
    Schulze-Bonhage, A.
    [J]. EPILEPSIA, 2006, 47 : 154 - 154
  • [10] The effects of chronic fluoxetine treatment following injury of medial frontal cortex in mice
    McAllister, Brendan B.
    Spanswick, Simon C.
    Patel, Payal P.
    Barneto, Alison A.
    Dyck, Richard H.
    [J]. BEHAVIOURAL BRAIN RESEARCH, 2015, 290 : 102 - 116
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