Childhood optic neuritis clinical features and outcome

被引：43

作者：

Absoud, Michael ^{[1
]}

Cummins, Carole ^{[1
]}

Desai, Nivedita ^{[2
]}

Gika, Artemis ^{[3
]}

McSweeney, Niamh ^{[2
]}

Munot, Pinki ^{[2
]}

Hemingway, Cheryl ^{[2
]}

Lim, Ming ^{[3
]}

Nischal, Ken K. ^{[4
]}

Wassmer, Evangeline ^{[5
]}

机构：

[1] Birmingham Childrens Hosp, Inst Child Hlth, Birmingham B4 6NH, W Midlands, England

[2] Great Ormond St Hosp Sick Children, Paediat Neurol Dept, London, England

[3] Evelina Childrens Hosp, Paediat Neurol Dept, London, England

[4] Great Ormond St Hosp Sick Children, Clin & Acad Dept Ophthalmol, London, England

[5] Birmingham Childrens Hosp, Paediat Neurol Dept, Birmingham B4 6NH, W Midlands, England

来源：

ARCHIVES OF DISEASE IN CHILDHOOD | 2011年 / 96卷 / 09期

关键词：

NEUROMYELITIS-OPTICA; MULTIPLE-SCLEROSIS; CHILDREN; RISK;

D O I：

10.1136/adc.2009.175422

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Aim To describe clinical features and outcome of a series of children with first-episode optic neuritis investigated in three paediatric neurology centres. Methods Databases were searched to identify children (<16 years) with optic neuritis and life table analysis was used. Results 44 children (female/male ratio 1.8) median age 10.9 years were followed up for median 1 year. Optic neuritis was unilateral in 43%. Maximal visual deficit was severe (<6/60) in 77%, with full recovery in 70%. Cumulative probability of developing MS (11/44) or NMO (3/44) at 2 years was 0.45. Relapsing optic neuritis was a strong predictor for development of MS or NMO. A positive MRI (>1 brain T2 hyperintense lesion) was a strong predictor for development of MS. Discussion Childhood optic neuritis is associated with severe visual deficit with good recovery. An initial abnormal MRI brain scan or relapsing optic neuritis should alert the clinician to MS or NMO diagnosis.

引用

页码：860 / 862

页数：3

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