Hendersine A, a novel isoquinoline alkaloid from Corydalis hendersonii

被引：17
|
作者：
Yin, Xu [1 ,2 ]
Bai, Ruifeng [1 ,2 ]
Guo, Qiang [1 ,2 ]
Su, Guozhu [1 ,2 ]
Wang, Jing [1 ,2 ]
Yang, Xinyao [1 ,2 ]
Li, Li [3 ,4 ]
Tu, Pengfei [1 ]
Chai, Xingyun [1 ]
机构：
[1] Beijing Univ Chinese Med, Modern Res Ctr Tradit Chinese Med, Beijing 100029, Peoples R China
[2] Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing 100102, Peoples R China
[3] Chinese Acad Med Sci, Inst Mat Med, Dept Med Chem, Beijing 100050, Peoples R China
[4] Peking Union Med Coll, Beijing 100050, Peoples R China
来源：
TETRAHEDRON LETTERS | 2016年 / 57卷 / 43期
基金：
中国国家自然科学基金;
关键词：
Corydalis hendersonii; Hendersines A and B; Isoquinoline alkaloids; Analgesic activity; H9c2 myocyte protection; PAIN; QUERCETIN; DRUGS;
D O I：
10.1016/j.tetlet.2016.09.064
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A pair of enantiomeric alkaloids, (+/-) hendersine A (la and lb), featuring an unprecedented couple pattern of an isoquinoline and a succinic acid derivative, a new isoquinoline hendersine B (2), and a known (+)-magnoflorine (3) were isolated from the EtOH extract of Corydalis hendersonii. Their structures were elucidated on the basis of spectroscopic data including HRESIMS, NMR, and experimental and calculated electronic circular dichroism (ECD). Compound 3 exhibited strong inhibitory effects against Ca2+ overload in glutamate-induced PC12 cells. Compounds 1-3 exhibited a protective effect against H9c2 myocyte injuries induced by LPS-stimulation conditioned medium. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4858 / 4862
页数：5
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