Aiming at the choice of data polarization mode in magnetotelluric 2D inversion, several 2D and 3D models are designed to study the difference between 3D response and 2D response, the choice of data polarization mode in 2D inversion, and 2D approximate interpretation of 3D data The research is divided into two parts one is the difference between 3D and 2D response, and the other is comparison of 2D inversion results The results manifest that in the 3D scenario the demand for approximate 2D structure in TE mode is much stricter than in TM mode When 3D effect is relatively severe, by applying 2D inversion to 3D data, the results show that the inversion model using only TM mode data is more valid, and the phantom structures are less than using TE mode or TE+TM mode In TM mode, the distortion of phase is less than apparent resistivity, so the weight of phase in inversion can be increased For 2D inversion of field data, TM mode only is the first choice, next is TE+TM, TE mode only is not proposed