A new method for the synthesis of N-substituted pyrroles

被引：4
|
作者：
Xue, Hai
Ma, Tao
Wang, Lin
Liu, Gang [1 ]
机构：
[1] Chinese Acad Med Sci, Inst Mat Med, Dept Synthet Med Chem, Beijing 100050, Peoples R China
来源：
CHINESE CHEMICAL LETTERS | 2010年 / 21卷 / 11期
基金：
中国国家自然科学基金;
关键词：
12-Oxo-calanolide A; Primary amine; N-Substituted pyrroles; Synthesis; ANTI-HIV ACTIVITY; REVERSE-TRANSCRIPTASE; FACILE SYNTHESIS; WILD-TYPE; CALANOLIDE; ANALOGS;
D O I：
10.1016/j.cclet.2010.04.030
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An unexpected reaction of 10-bromomethyl-12-oxocalanolide A (2) with primary amine was demonstrated and studied. Consequentially, a new method for the preparation of N-substituted pyrroles starting from gamma-halo-alpha,beta-unsaturated ketone was presented. (C) 2010 Gang Liu. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
引用
收藏
页码：1291 / 1294
页数：4
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