Sesquiterpenoids from the Resinous Exudates of Commiphora myrrha and Their Neuroprotective Effects

被引：41

作者：

Xu, Jing ^{[1
,2
]}

Guo, Yuanqiang ^{[1
,2
]}

Li, Yushan ^{[3
]}

Zhao, Peng ^{[4
]}

Liu, Cuizhou ^{[1
,2
]}

Ma, Yonggang ^{[1
,2
]}

Gao, Jie ^{[1
,2
]}

Hou, Wenbin ^{[5
]}

Zhang, Tiejun ^{[5
]}

机构：

[1] Nankai Univ, Coll Pharm, Tianjin 300071, Peoples R China

[2] Nankai Univ, Tianjin Key Lab Mol Drug Res, Tianjin 300071, Peoples R China

[3] Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Shenyang, Peoples R China

[4] Tianjin Childrens Hosp, Tianjin, Peoples R China

[5] Tianjin Inst Pharmaceut Res, Tianjin, Peoples R China

来源：

PLANTA MEDICA | 2011年 / 77卷 / 18期

关键词：

Commiphora myrrha; Burseraceae; furanosesquiterpene; neuroprotective effect; BIOACTIVE CONSTITUENTS; GUM RESINS; TRITERPENES; OPOBALSAMUM; WIGHTII; ANTIBACTERIAL; ERLANGERIANA; BURSERACEAE; TERPENOIDS; MUKUL;

D O I：

10.1055/s-0031-1280087

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Ten new furanosesquiterpenoids, myrrhterpenoids A-J (1-10), together with eight known analogues (11-18), were isolated from the resinous exudates of Commiphora myrrha. Their structures and relative configurations were elucidated by spectroscopic methods (IR, ESIMS, HRESIMS, 1D and 2D NMR) and by the ChemDraw 3D modeling using MM2. All isolated furanosesquiterpenes showed neuroprotective effects against MPP(+)-induced neuronal cell death in SH-SY5Y cells.

引用

页码：2023 / 2028

页数：6

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