Enantiomer resolution screening strategy using multiple immobilised polysaccharide-based chiral stationary phases

CHIRALPAK IA, CHIRALPAK IB and CHIRALPAK IC are a new generation of chiral packing materials for resolution of enantiomers by chromatography. They are all prepared by chemical immobilisation of the respective polysaccharide derivatives onto a supporting silica matrix. The present article aims to establish an understanding of the global enantioselective profiles of this series of chiral stationary phases (CSPs). When used in combination, high success rates for enantiomer resolution could be achieved. These three CSPs exhibit an exceptional level of complementary chiral recognition characteristics by applying common screening and method optimisation strategies. (c) 2007 Elsevier B.V. All rights reserved.