Botanicals for the prevention and treatment of cutaneous melanoma

被引：21

作者：

Syed, Deeba N. ^{[1
]}

Mukhtar, Hasan ^{[1
]}

机构：

[1] Univ Wisconsin, Dept Dermatol, Madison, WI 53715 USA

来源：

PIGMENT CELL & MELANOMA RESEARCH | 2011年 / 24卷 / 04期

关键词：

botanicals; melanoma; DIFFERENTIATION-INDUCING ACTIVITY; GENISTEIN INHIBITS GROWTH; CELLS IN-VITRO; FACTOR-KAPPA-B; MALIGNANT-MELANOMA; UP-REGULATION; GREEN TEA; ANTIANGIOGENIC ACTIVITY; ULTRAVIOLET-RADIATION; SILYMARINS PROTECTION;

D O I：

10.1111/j.1755-148X.2011.00851.x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cutaneous melanoma, a cancer of melanocytes, when detected at later stages is arguably one of the most lethal cancers and the cause of more years of lost life than any other cancer among young adults. There is no standard therapy for advanced-stage melanoma and the median survival time for patients with metastatic melanoma is <1 yr. An urgent need for novel strategies against melanoma has directed research towards the development of new chemotherapeutic and biologic agents that can target the tumor by several different mechanisms. Recently, several dietary agents are being investigated for their role in the prevention and treatment of various forms of cancer and may represent the future modality of the treatment. Here, we have reviewed emerging data on botanicals that are showing promise for their potential inhibitory effect against cutaneous melanoma.

引用

页码：688 / 702

页数：15

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